ISSN:
1432-1041
Keywords:
saturation absorption
;
dose-dependent absorption
;
Michaelis-Menten kinetics
;
chlorthiazide
;
phenylbutazone
;
naproxen
;
cardiac glycosides
;
tetracycline
;
phenytoin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary It is shown that the absorption of phenylbutazone, naproxen, and chlorthiazide is governed by a dose limiting mechanism. This dose dependency may be explained by a saturation absorption process mathematically obeying Michaelis-Menten type kinetics. Observed dose relationships for tetracycline, fenclozic acid and related compounds, phenytoin, and possibly digoxin and digitoxin may be explained if a saturable process in absorption is postulated. This behavior may be produced by insolubility of the drug compound, a limited “window of absorption” in the gastrointestinal tract, or a capacity limited absorption because of the carrier or the transport mechanism involved. The need for suitably designed dose response studies with new drug compounds is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00545976
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