ISSN:
1573-6830
Keywords:
human
;
hypothalamus
;
pituitary
;
interleukin-10
;
neuroendocrine system
;
immune system
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary 1. Recent data have shown that interleukin-10 (IL-10) is expressed and acts in mouse pituitary tumor cells and freshly isolated mouse pituitaries. 2. In this study, we show that poly(A+ RNA derived from normal human pituitary and hypothalamus expresses IL-10 message. 3. The majority of transcripts was likely from the pituitary and hypothalamus, and not from lymphocytes in the pituitary and hypothalamic vasculature, since both IL-10 and interferon-γ mRNA levels, compared to equivalent amounts of RNA from peripheral blood lymphocytes, were much lower. 4. These results indicate that IL-10 may function in human neuroendocrine processes as it does in the murine system, thus serving as an important signal molecule for bidirectional communication between the neuroendocrine and the immune systems.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02073335
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