ISSN:
1435-1463
Keywords:
Schizophrenia
;
neuropathology
;
cytoarchitectonic abnormalities
;
developmental disorder
;
allocortex
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Sixty-four autopsied brains of schizophrenic patients were neuropathologically examined and compared with 10 brains of non-schizophrenic controls. Clinical diagnoses were established retrospectively according to the Research Diagnostic Criteria and the International Classification of Diseases. We found: 1. brains without deviations of the sulcogyral pattern of the temporal lobe or abnormal gross configuration (n=22); 2. brains with abnormal sulcogyral pattern of the temporal lobe or abnormal gross configuration (n=42): a) with definite cytoarchitectonic abnormalities of the rostral entorhinal region in the parahippocampal gyrus and, in 16 cases only, in the ventral insular cortex (n=20); b) with equivocal changes of the cytoarchitecture in these two regions (n=22). Generally, these anatomical abnormalities were asymmetric. The histological findings in the two limbic regions consisted mainly of poorly developed structure in the upper layers, with a heterotopic displacement of single groups of nerve cells in the entorhinal region. Particularly, the disturbed structure of the second layer Pre-α in medial and central fields of the entorhinal region, situated in the parahippocampal gyrus (group 2 a), suggests a disturbance of neuronal migration in a later phase of cortical development.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01249090
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