ISSN:
1435-1463
Keywords:
Keywords: Alzheimer's disease
;
nitric oxide synthase 3 (NOS3)
;
polymorphism
;
association study.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary. Recently a significant association of a missense mutation (Glu298Asp) of the endothelial nitric oxide synthase (NOS3) gene with late-onset Alzheimer's disease (LOAD) was reported. We tried to replicate this finding in a Japanese sample of 121 patients with LOAD, 51 with early-onset AD (EOAD), and 165 medical controls. However, the genotype and allelic distributions for the Glu298Asp polymorphism were similar for these three groups, suggesting that the Glu298Asp polymorphism of the NOS3 gene has no relevance to the development of AD in Japanese.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007020070053
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