ISSN:
1573-8221
Keywords:
FMRFa
;
opioids
;
hypertension
;
adrenoreceptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of the peptide FMRFa on arterial pressure, heart rate, and respiratory rate is examined in anesthetized rats. It is demonstrated that the effect of FMRFa is similar to that of epinephrine and is characterized by transient hypertension against the background of bradycardia and decreased respiratory rate followed by hypotensive phase. Opiate antagonists and agonists do not modify the effect of FMRFa. Pressor effect of FMRFa is inhibited by Aminazine and is abolished by dihydroergotamine, while clopheline, reserpine, propranolol, Dimedrol, and adrenalectomy have no appreciable effect on it. It is suggested that the effects of FMRFa are realized via vascular adrenoreceptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445664
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