ISSN:
1573-7330
Keywords:
in vitro fertilization-embryo transfer
;
ovarian hyperstimulation
;
clomiphene citrate
;
human menopausal gonadotropins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Various protocols have been utilized for stimulation of multiple ovarian follicles in patients undergoing in vitro fertilization-embryo transfer (IVF-ET). Previous studies have suggested that the combination of clomiphene citrate (CC) and human menopausal gonadotropins (hMG) is superior to either CC or hMG alone in terms of follicular development, oocyte recovery, and embryo transfer. However, no significant increase in viable pregnancy rates has been reported with any of the protocols. This report examines five different CC/hMG protocols. While differences were seen in terms of serum estradiol response and fertilization rates of mature oocytes among the various protocols, no significant differences were found in terms of follicular development, oocyte recovery, embryo transfer, or pregnancy. The pregnancy rate in IVF-ET appears unaffected by variations in the dose and timing of CC and hMG in a combination protocol.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01555433
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