ISSN:
1432-1041
Keywords:
brinase
;
phenprocoumon
;
Buerger's disease
;
proteolytic enzymes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 patients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused a significant increase in calf and ankle pressure index. At six months follow-up, the clinical results were statistically significant in favour of Brinase when all patients were considered, but not if 10 patients with Buerger's disease were omitted from the analysis. Patients treated with a combination of Brinase and coumarins had a better clinical outcome than patients receiving either treatment on its own.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00562056
Permalink
