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Dependence of nitrogen- and phosphorus-regulation of β-lactam antibiotic production byStreptomyces clavuligerus on aeration level (1995)

Fang, A ; Demain, A L

Springer

Journal of industrial microbiology and biotechnology 15 (1995), S. 407-410

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ISSN: 1476-5535

Keywords: nitrogen regulation ; phosphorus regulation ; cephamycin ; secondary metabolism ; antibiotics ; Streptomyces clavuligerus

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: Abstract Interference with β-lactam production inStreptomyces clavuligerus by ammonium and phosphate ions, normally observed with optimum levels of aeration, was eliminated by restriction of the air supply. Under such a restriction, ammonium slightly stimulated and phosphate markedly stimulated β-lactam antibiotic production. These are rare examples of ‘regulation reversal’ by an environmental modification.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01569965

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