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Digitale Medien

Tracer transport and metabolism in a patient with juvenile pilocytic astrocytoma. A PET study (1998)

Roelcke, U. ; Radü, E.W. ; Hausmann, O. ; [weitere]

Springer

Journal of neuro-oncology 36 (1998), S. 279-283

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ISSN: 1573-7373

Schlagwort(e): pilocytic astrocytoma ; positron emission tomography ; blood-brain barrier ; glucose metabolism ; PET ; FDG

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract We studied a patient with juvenile pilocytic astrocytoma (JPA) using positron emission tomography (PET), 18 F-fluorodeoxyglucose (FDG),11 C-methionine (MET), and 82Rubidium (RUB). Non-linear fitting and multiple time graphical plotting of the dynamic PET data revealed values for tumor plasma volume, blood-brain barrier transport rate constants and tracer distribution volume in the range of glioblastomas and meningiomas, or higher. Likewise, the steady-state accumulation of MET and FDG was increased. With regard to the known vascular composition of JPA, our data suggest that increased transport and distribution considerably contribute to the high net tracer uptake observed in this tumor.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1005898109520

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