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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 38 (1990), S. 329-334 
    ISSN: 1432-1041
    Keywords: prescription monitoring ; drug dosage ; Sweden ; Jämtland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Prescribed doses of drugs for which individualisation of dosage is deemed necessary were recorded from one national and one local Swedish prescription monitoring study for the years 1976, 1982 and 1985. Dose patterns were analysed in order to determine whether the practice of individualising drug doses had become more widely adopted by physicians. Amongst drugs eliminated primarily by metabolism, (propranolol and amitriptyline were prescribed in highly variable doses (30-fold or more). The three commonest doses of these agents accounted for about 60% of the prescriptions. In general, doses decreased with increasing patient age. Prescribing practices for piroxicam differed markedly from those of propranolol and amitriptyline, with one fixed dose of piroxicam accounting for about 90% of all prescriptions. For drugs eliminated mainly by renal excretion (digoxin, cimetidine and atenolol) there was an 8–10-fold variation in the prescribed doses. The most frequent dose of these drugs accounted for 40–60% of the prescriptions. Doses of cimetidine and atenolol were lowered only in the oldest patients. The doses of digoxin decreased more evenly with increasing age, and were reduced in elderly patients on long-term maintenance therapy. The difference in digoxin dose between young and old patients increased during the study period. Prescription monitoring as a method for following-up drug usage may be instrumental in evaluating the effect of drug educational efforts.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 39 (1990), S. 207-210 
    ISSN: 1432-1041
    Keywords: drug use ; defined daily dose (DDD) ; estimation of drug use ; prescription monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To evaluate the accuracy of the DDD per 1000 inhabitants per unit time as an estimate of the fraction of drug users within a population, DDD figures have been compared with the proportion of apparent drug users, i.e. individuals in the population for who a prescriptions had been dispensed. An individual-based prescription monitoring project provided the necessary data for eight drugs representing continuous long-term medication, short-term medication and medication falling in between those two categories. For digoxin, the long-term drug, the number of DDD/1000 inhabitants/day was about 40% below the proportion of apparent drug users. The DDD figure for antibiotics ranged from 4% below to 28% above the apparent users, and for the remaining drugs it ranged from 17% below (bendroflumethiazide, 1982) to 80% below (naproxen, 1985). The DDD methodology is a valuable first step in overall drug use measurement, but for more precise estimates of drug use it must be supplemented by other techniques.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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