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Export of proteins across membranes: The helix reversion hypothesis (1989)

Shinde, U. P. ; Guru Row, T. N. ; Mawal, Y. R.

Springer

Bioscience reports 9 (1989), S. 737-745

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ISSN: 1573-4935

Keywords: protein export ; conformational changes ; leader peptides ; hairpin helix

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01114812

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