ISSN:
1573-3904
Keywords:
backbone cyclic peptides
;
bovine pancreatic trypsin inhibitor
;
BPTI
;
peptidomimetic
;
proteinomimetic
;
4-thioproline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The synthesis of a backbone bicyclic nonapeptide that mimics the binding site of bovine pancreatic trypsin inhibitor (BPTI) is described. The BPTI mimetic, which contains cis-thioproline replacing Cys38 of the protein, inhibits trypsin with a Ki of 76 μM.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008888327446
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