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Pharmacokinetic study of chloramphenicol in patients with liver disease (1981)

Narang, A. P. S. ; Datta, D. V. ; Nath, N. ; [et al.]

Springer

European journal of clinical pharmacology 20 (1981), S. 479-483

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ISSN: 1432-1041

Keywords: chloramphenicol ; liver disease ; pharmacokinetics ; intravenous administration ; serum albumin ; prothrombin time index

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under the time — concentration curve (AUC) showed an increase. The t1/2 of chloramphenicol showed a significant correlation with serum albumin and prothrombin time index.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00542103

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