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  • 1
    Electronic Resource
    Electronic Resource
    Sol-Gel Carrier Systems for Controlled Drug Delivery (1998)
    Springer
    Journal of sol gel science and technology 13 (1998), S. 277-281 
    Details
    ISSN: 1573-4846
    Keywords: silica ; composites ; nifedipine ; polyethyleneglycol ; controlled release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Embedding of the well-known coronary therapeuticum nifedipine into a modified silica matrix by the sol-gel technique allows its releasing behavior to be controlled to a high degree. The liberation rate is proportional to temperature and is increased by the addition of penetration agents such as sorbitol, but is inversely proportional to particle size and is decreased by modification of the silica matrix with methyl-triethoxysilane or polyethylene-glycol. It is presumed that the drug is dispersed in the gel matrix and that diffusion occurs through solvent-filled capillary channels. The liberation rate is governed by the relationship between the rates of dissolution and diffusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008603622543
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Model Investigations of Controlled Release of Bioactive Compounds from Thin Metal Oxide Layers (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 651-654 
    Details
    ISSN: 1573-4846
    Keywords: silica ; composite layers ; controlled release ; penetration agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Thin composite layers of silica with incorporated bioactive organic compounds (BOC) can be prepared by mixing metal oxide sols with dissolved BOC and coating with a conventional film coating machine. The release of antibacterial benzoic acid from the silica layers into a surrounding aqueous medium can be controlled by the mass ratio of silica to benzoic acid, by modification of the silica matrix and by addition of soluble or swelling penetration agents, respectively. Therefore, such composite materials are applicable for controlled release sytems in medicine and biology with excellent long-time effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018376427531
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Model investigations of controlled release of bioactive compounds from thin metal oxide layers (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 651-654 
    Details
    ISSN: 1573-4846
    Keywords: silica ; composite layers ; controlled release ; penetration agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Thin composite layers of silica with incorporated bioactive organic compounds (BOC) can be prepared by mixing metal oxide sols with dissolved BOC and coating with a conventional film coating machine. The release of antibacterial benzoic acid from the silica layers into a surrounding aqueous medium can be controlled by the mass ratio of silica to benzoic acid, by modification of the silica matrix and by addition of soluble or swelling penetration agents, respectively. Therefore, such composite materials are applicable for controlled release sytems in medicine and biology with excellent long-time effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436917
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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