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Digitale Medien

Relative configuration of thioridazine enantiomers (1991)

Patrick, Kennerly S. ; Singletary, Joan L.

New York, NY [u.a.] : Wiley-Blackwell

Chirality 3 (1991), S. 208-211

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ISSN: 0899-0042

Schlagwort(e): neuroleptic ; dopamine ; receptor ; enantioselectivity ; schizophrenia ; stereochemistry ; isomers ; racemate ; Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The relative configuration of the enantiomers of thioridazine was defined to explore the stereochemistry associated with the selective binding of (-)-thioridazine to dopamine D-1 receptors and (+)-thioridazine to D-2 receptors. Using a seven-step stereoconservative synthesis, (-)-(S)-2-piperidinecarboxylic acid was converted to (-)-(S*)-2-(2-chloroethyl)-1-methylpiperidine, a literature (-)-thioridazine synthetic precursor. Accordingly, (-)- and (+)-thioridazine are the (S)- and (R)-enantiomers, respectively.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/chir.530030312

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