ISSN:
1573-1111
Keywords:
β-cyclodextrin
;
inclusion complex
;
stoichiometry
;
violacein
;
induced circular dichroism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The formation of inclusion compounds between violacein andβ-cyclodextrin was studied by diffusion and circulardichroism measurements. The present work was undertaken to explore the feasibilityof the β-cyclodextrin in reducing the toxicity and enhancing the antitumoral efficacy ofviolacein by forming an inclusion complex. The results of the two experimentsare in good agreement, suggesting the formation of 1 : 1 and 1 : 2 complexes.The diffusion coefficient measurements enabled estimates of the sizes of the complexesinvolved. From the circular dichroism and computational calculations it was possibleto view a preference for inclusion of the most polar part of the molecule to form a1 : 2 inclusion complex. We expect that this work proves the potential of thesetechniques to determining complex stoichiometry.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008186706573
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