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Character of the histamine-liberating action of MCD-peptide from bee venom (1977)

Gushchin, I. S. ; Miroshnikov, A. I. ; Martynov, V. I.

Springer

Bulletin of experimental biology and medicine 84 (1977), S. 1013-1015

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ISSN: 1573-8221

Keywords: MCD-peptide ; mellitin ; substance 48/80 ; mast cells ; liberation of histamine

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The histamine-liberating action of MCD-peptide and of mellitin, isolated from bee venom, and of substance 48/80 was studied on isolated rat mast cells. The action of MCD-peptide is similar to that of the noncytotoxic agent 48/80 in the character of the dose-response curves, latent period, and temperature-dependence of histamine liberation. The liberation of histamine induced by MCD-peptide is an energy-dependent process but is independent of cyclic AMP.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00798533

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