ISSN:
1436-2813
Keywords:
granulocyte colony-stimulating factor
;
surgical stress
;
elective gastrointestinal surgery
;
PMN function
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To characterize the changes in perioperative plasma granulocyte colony-stimulating factor (G-CSF) and analyze the effect of surgical stress on its kinetics, 41 patients undergoing gastrointestinal surgery with varying degrees of surgical stress were examined. The plasma levels of G-CSF significantly increased immediately after the operation, probably in response to surgical injury. This elevation was much higher in the 15 esophagectomy patients, at 883±300 pg/ml on postoperative day (POD) O, than in the 14 gastrectomy patients, with a value of 233±151 on POD O, (P〈0.01) or in the 12 cholecystectomy patients, with a value of 64±41 on POD 1 (P〈0.01). These findings led us to conclude that G-CSF levels increase significantly in the immediate postoperative period and are most likely associated with the degree of surgical stress. In addition, we studied the priming effect of G-CSF on polymorphonuclear leukocytes (PMNs). G-CSF enhanced PMN superoxide anion (O− 2) production and luminol-dependent chemiluminescence (CL) induced by opsonized zymosan in a dose-dependent manner. A significant enhancement was seen in the G-CSF level (1 ng/ml) which was almost the same as the maximum G-CSF level in the esophagectomy patients. Furthermore, postoperative PMN activation occurred after the elevation of plasma G-CSF. Thus, we propose that elevated G-CSF may act as one of the mediators which activate PMN function postoperatively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00311429
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