ISSN:
1573-7217
Keywords:
breast cancer
;
c-neu/erbB2 oncogene
;
diet
;
dietary fiber
;
transgenic mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Breast cancer is one of the most commoncancers in women. The laboratory rat treated withstrong carcinogen is the most commonly used animalmodel for study of breast cancer. Transgenic mouselines with homologues of human breast cancer oncogeneshave been developed. The transgenic mouse line TG.NKwith c-neu, the human breast cancer oncogene homologueof erbB2, was evaluated to determine its suitabilityfor study of intervention strategies to delay/prevent thedevelopment of breast cancer. There were no palpablemammary tumor masses up to 22-weeks of age,and almost all mice fed a purified dietdeveloped palpable mammary tumors by 28-weeks of age.Nonpurified diets decreased the incidence and multiplicity, anddelayed the development of mammary tumors as comparedto a purified diet. Increasing the fiber contentof nonpurified diet decreased the tumor incidence further.There is approximately a 19-week interval between weaningand development of palpable mammary masses to evaluateintervention strategies to delay or prevent the developmentof mammary cancer in the TG.NK mouse model.Fiber from nonpurified cereal ingredients appears to behighly beneficial in delaying the development of mammarycancer in TG.NK mice, and this observation isin agreement with human epidemiological findings. Therefore, theTG.NK transgenic mouse with oncogene c-neu (erbB2), appearsto be a useful animal model for evaluationof dietary intervention strategies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1005822318256
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