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  • 1
    Electronic Resource
    Electronic Resource
    Transepithelial Transport of Levofloxacin in the Isolated Perfused Rat Kidney (2000)
    Springer
    Pharmaceutical research 17 (2000), S. 236-241 
    Details
    ISSN: 1573-904X
    Keywords: quinolones ; transport ; renal secretion ; isolated perfused kidney ; moment analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The transepithelial transport of levofloxacin was evaluatedin the isolated perfused kidney to investigate its renal secretorymechanisms. Methods. Levofloxacin was instantaneously administered into the renalartery together with inulin and Evans blue-labeled albumin, and thesingle-pass dilution curves of the renal venous and urinary outflowwere determined in the absence or presence of various compounds.Kinetic parameters were computed based on non-compartmentmoment analysis. Results. The ratio of fractional excretion to filtration fraction (FE/FF)for levofloxacin was 2.99 ± 0.18, indicating the involvement of tubularsecretion. In the presence of cimetidine and quinolones, the FE/FF oflevofloxacin was significantly decreased and the transepithelial meantransit time (¯Tcell) of levofloxacin was prolonged. The ¯Tcell showed anegative correlation with renal secretion of levofloxacin, while thevolume of distribution of levofloxacin showed no correlation. Conclusions. Transport on the brush-border membrane plays adetermining step in the renal secretion of levofloxacin, and cimetidineand quinolones interact with levofloxacin transport on thebrush-border membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007533817835
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Decreased Transport of p-Aminohippurate in Renal Basolateral Membranes Isolated from Rats with Acute Renal Failure (1989)
    Springer
    Pharmaceutical research 6 (1989), S. 954-957 
    Details
    ISSN: 1573-904X
    Keywords: p-aminohippurate ; tetraethylammonium ; transport ; basolateral membrane ; kidney ; acute renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Transport of D-glucose, p-aminohippurate (organic anion), and tetraethylammonium (organic cation) was studied in the renal basolateral membrane vesicles isolated from rats with acute renal failure (ARF). ARF was induced by a single injection of uranyl nitrate. Carrier-mediated transport of p-aminohippurate, estimated under anion–anion exchange condition, was significantly decreased in basolateral membrane vesicles isolated from ARF rats. In contrast, there were no significant differences in D-glucose and tetraethylammonium uptake between normal and ARF rats. When normal basolateral membrane vesicles were incubated in vitro with uranyl nitrate, no significant inhibition in p-aminohippurate uptake was observed. These results suggest that organic anion transport is decreased in renal basolateral membranes from ARF rats, and this transport dysfunction cannot be explained by the direct interaction of uranyl nitrate with the organic anion carrier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015993429458
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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