ISSN:
1573-6881
Keywords:
Chemotherapy
;
ATP
;
drug transport
;
colchicine
;
actinomycin D
;
doxorubicin
;
vinblastine
;
vincristine
;
introns
;
evolution
;
P-glycoprotein
;
transmembrane domains
;
MDR1 gene
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Physics
Notes:
Abstract Multidrug resistance in animal cells is defined as the simultaneous resistance to a variety of compounds which appear to be structurally and mechanistically unrelated. One type of multidrug resistance is characterized by the decreased accumulation of hydrophobic natural product drugs, a phenotype which is mediated by an ATP-dependent integral membrane multidrug transporter termed P-glycoprotein or P170. The gene coding for P170 is calledMDR. The nucleotide-binding domain of P-glycoprotein shares sequence homology with a family of bacterial permease ATP-binding components. In addition, P170 as a whole is structurally very similar to a number of prokaryotic and eukaryotic proteins believed to be involved in transport activities. This review summarizes our current knowledge of the molecular biology and clinical significance ofMDR expression and P-glycoprotein transport activity, as well as some theories about the function of this protein in normal cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00762963
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