ISSN:
1573-1111
Keywords:
Sodium deoxycholate
;
bilirubin-IXα
;
mesobilirubins-XIIIα and IVα
;
xanthobilirubic acid
;
circular dichroism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Intramolecularly hydrogen-bonded, bichromophoric tetrapyrrole pigments, bilirubin-IXα and mesobilirubin-XIIIα, adopt either of two enantiomeric conformations which are in dynamic equilibrium in solution. InpH 8 aqueous sodium deoxycholate solutions, chiral micelles preferentially select one conformational enantiomer, and the solutions exhibit a bisignate circular dichroism Cotton effect in the vicinity of the bilirubin long wavelength electronic transition. Exciton coupling theory indicates a predominance of the left-handed (or negative) chirality bilirubin conformational enantiomer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00657500
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