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  • 1
    Electronic Resource
    Electronic Resource
    G banding in cytogenetic study of hemoblastoses (1975)
    Springer
    Human genetics 〈Berlin〉 26 (1975), S. 335-342 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary G banding was used in the study of the karyotype of malignant cells in 10 patients: 5 with CML (3 in blastic crisis), 3 with AL and 2 with lymphosarcomas. In all cases of CML 22q-(Ph1-chromosome) and 9+ were present in leukemic cells. An i(17q) was observed in the karyotype of out of 3 patients in blastic crisis of CML. In AL and lymphosarcomas small chromosome rearrangements were revealed and the origin of marker chromosomes could be established by the aid of G banding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285385
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  • 2
    Electronic Resource
    Electronic Resource
    Certain patterns of karyotype evolution in chronic myelogeneous leukaemia (1975)
    Springer
    Human genetics 〈Berlin〉 30 (1975), S. 113-119 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The study of chromosome banding pattern of leukaemic cells in 15 patients with CML revealed t(9;22) in all cases. Similar additional chromosome abnormalities were observed in the terminal stage of the disease in 5 of 9 patients with aneuploid cell lines. The most frequent abnormalities were i(17q) and trisomy 8. The regularities of karyotype evolution in the terminal stage of CML are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291943
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  • 3
    Electronic Resource
    Electronic Resource
    Marker chromosome 14q+ in two non-Burkitt lymphomas (1975)
    Springer
    Human genetics 〈Berlin〉 30 (1975), S. 109-112 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Marker chromosome 14q+, similar to the specific marker of the Burkitt lymphoma, was revealed in all malignant blood cells of a patient with generalized lymphosarcoma, in all lymph node cells, and in a part of the blood cells of a patient with chronic lymphocytic leukaemia. Possible causes of this similarity are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291942
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  • 4
    Electronic Resource
    Electronic Resource
    Chromosomes in acute nonlymphocytic leukemia (1986)
    Springer
    Human genetics 〈Berlin〉 73 (1986), S. 137-146 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The karyotype of leukemic cells was studied in 88 acute nonlymphocytic leukemia (ANLL) patients. Chromosome abnormalities were discovered in 78.4% of all patients and in 72.5% of the 69 patients studied before treatment. Characteristic abnormalities: translocations 8;21, 15;17, 9;22 or 6;9, rearrangements of 11q, gain of chromosomes 8 or 21, and loss or deletion of chromosomes 5 or 7 were detected in 56 of 69 patients with abnormal karyotypes. Translocation 8;21 was revealed in 27 patients; 20 of them had M2 FAB-form, four had M1, and three had M4. In patients with t(8;21) the incidence of complete remission was higher and the duration of first remission and survival longer than in patients with other abnormalities or with a normal karyotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291604
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  • 5
    Electronic Resource
    Electronic Resource
    Chromosomal rearrangements with a common breakpoint at 6p23 in five cases of myeloid leukemia (1983)
    Springer
    Human genetics 〈Berlin〉 64 (1983), S. 254-256 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Rearrangement of the short arm of chromosome 6 with a breakpoint at 6p23 was found in five patients with myeloid leukemia. Three of them had different morphological variants of AML (M2, M3, M4) and two blastic crisis of Ph1 negative and Ph1 positive CML. Identical translocation, t(6;9)(p23;q34), was revealed in two patients. One of them had AML (M2), the other blastic crisis of Ph1 negative CML. The blast cells of the last patient were morphologically similar to those in the M2 variant of AML. Translocation (6;9)(q23;q34) was also detected in two AML patients of Rowley and Potter (1976). The role of the breakpoint at 6p23 in myeloid malignancies needs further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279404
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  • 6
    Electronic Resource
    Electronic Resource
    Correlations between the clinical course, characteristics of blast cells, and karyotype patterns in chronic myeloid leukemia (1981)
    Springer
    Human genetics 〈Berlin〉 58 (1981), S. 285-293 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Results of chromosome studies of blood and bone marrow cells from 101 patients with Ph1 positive chronic myeloid leukemia (CML) confirm the assumption that clinical and morphologic manifestations of the disease correlate with karyotype peculiarities of leukemic cells. Several variants of the clinical course of CML may be distinguished. One is the variant with a short chronic phase and a comparatively long terminal phase. In blastic crisis the blast cells are peroxidase negative and do not possess cytoplasmic inclusions. Acute transformation occurs without any additional chromosome damage. The second, more common form is less severe because of longer chronic phase but it has a short and grave acute stage. The blast cells present definite signs of myeloid differentiation, they have basophilic or neutrophilic cytoplasmic granules and are peroxidase positive. Marker i(17q) often combined with trisomy 8 is a characteristic chromosome abnormality in the terminal stage of this variant. The third type has an extremely long chronic phase but ends in a rapidly progressing severe and resistant to therapy “lymphoid” blastic crisis. Blast cells have typical “lymphoid” morphology, they are peroxidase negative and contain granular PAS positive substance. Various additional chromosome changes appear in the terminal stage. Future studies of a larger series of patients may possibly reveal more CML variants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294925
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  • 7
    Electronic Resource
    Electronic Resource
    Chromosomal characteristics of malignant lymphoma (1989)
    Springer
    Human genetics 〈Berlin〉 82 (1989), S. 343-348 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Results of a cytogenetic and morphological study of 60 malignant lymphomas (ML) are presented. The most often observed chromosome abnormalities were rearrangements involving 14q32, 11q13, 11q21-23, 6q15, 6q21, 12p11-12, 17p11-12, and extra chromosomes 18, 3, 21 and 7. Translocations involving 14q32, leading to the appearance of marker 14q+, were noted in 41% of the tumors. Strict correlations between karyotype and morphology of ML were not seen. However, rearrangements of 11q were mostly found in lowgrade tumors and markers 6q-in high-grade tumors. The absence of t(14;18), which is regarded to be the most common abnormality in ML, and an unusually high incidence of t(11;14) in our series confirm the uneven geographical distribution of ML with these translocations. Chromosome abnormalities in ML and acute lymphoblastic leukemia are compared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273995
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  • 8
    Electronic Resource
    Electronic Resource
    Karyotype pecularities of human colorectal adenocarcinomas (1991)
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 491-496 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The data of the chromosome abnormalities in 15 colorectal tumors are presented. Rearrangements of the short arm of chromosome 17, leading to deletions of this arm or its part were noted in 12 tumors; in 2 other cases, one of the homologs of pair 17 was lost. The losses of at least one homolog of other chromosomal pairs were also found: chromosome 18, in 12 out of 13 cases with fully identified numerical abnormalities; chromosome 5, in 6 tumors; chromosome 21, in 5 cases; chromosomes 4, 15, and 22, in 4 cases each. Additional homologs of pair 20 were observed in 6 tumors, extra 8q was found in 5 tumors, and extra 13q in 6 cases. Rearrangements of the short arm of chromosome 1 and the long arm of chromosome 11 characterized 6 tumors each. The data recorded in our series differ from the data of other authors in two respects: the high incidence of the loss of sex chromosomes and the rearrangements of the long arm of chromosome 9. X chromosomes were missing in 4 out of 7 tumors in females, and Y chromosomes were absent in 5 out of 8 tumors in males. The long arm of chromosome 9 was rearranged in 8 cases, in 5 of them the breakpoint being at 9q22. Cytological manifestations of gene amplification (double minutes or multiple microchromosomes) were noted in 6 tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194640
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  • 9
    Electronic Resource
    Electronic Resource
    Unusual translocation (10;22) in chronic myelogenous leukemia (1977)
    Springer
    Human genetics 〈Berlin〉 39 (1977), S. 127-129 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273163
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  • 10
    Electronic Resource
    Electronic Resource
    Chromosome abnormalities and clinical and morphologic manifestations of chronic myeloid leukemia (1978)
    Springer
    Human genetics 〈Berlin〉 41 (1978), S. 143-156 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Forty cases of chronic myeloid leukemia (CML) were studied and subgroups of cases with similar chromosomal abnormalities in terminal stage were defined. Certain correlations were observed between the type of chromosomal changes, and clinical and morphologic manifestations of the disease: (1) It seems that, in cases without any karyotype changes other than translocation (9;22), the terminal stage is longer and milder than in cases with additional chromosomal abnormalities; (2) cases with marker i(17q) are clinically and morphologically rather uniform and are characterized by distinct signs of myeloid differentiation of blast cells, absent in other cases; (3) in cases with various atypical chromosomal abnormalities, the course of the terminal stage is the most rapid and grave. The blast cells differ from myeloblasts and resemble lymphoid elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273096
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