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Digitale Medien

Application of thermogravimetry in the quality control of mebendazole (1997)

Macêdo, Rui Oliveira ; Gouveia de Souza, Antonio ; Miriam, Ana ; [weitere]

Springer

Journal of thermal analysis and calorimetry 49 (1997), S. 937-941

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Details

ISSN: 1572-8943

Schlagwort(e): kinetics ; mebendazole ; quality control ; technology

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract A study was made of the thermal behavior of the starting materials, their mixtures and the resulting mebendazole tablets. The thermal curves were obtained with a Shimadzu thermobalance, model TGA-50, using an air flow of 50 mL min−1 and a heating rate of 10°C min−1 in the temperature interval 30–900°C. The reaction constant velocities for the mebendazole salt and tablets were determined isothermally, using the Arrhenius expression. The thermal stability of mebendazole tablets is lower than that of the mebendazole salt, due to the presence of starch and lactose in the composition. Analysis of the data reveals that thermogravimetry is a powerful tool in pharmaceutical technology and quality control.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01996779

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