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Digitale Medien

Circadian distribution of motor activity and immobility in narcolepsy: Assessment with continuous motor activity monitoring (1995)

MIDDELKOOP, HUUB A. M. ; LAMMERS, GERT JAN ; HILTEN, BOB J. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Psychophysiology 32 (1995), S. 0

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ISSN: 1469-8986

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin , Psychologie

Notizen: The circadian distribution of motor activity and immobility of 14 unmedicated narcoleptics and matched controls was evaluated by monitoring continuous wrist motor activity 5 successive days and nights at home. Sleep was also assessed by sleep logs. The amplitude of the circadian rhythm of motor activity and immobility was significantly lower in narcoleptics than in controls. The variables that best distinguish narcoleptics from controls were the diurnal and nocturnal mean duration of uninterrupted immobility, which can be explained by excessive daytime sleepiness and frequent nocturnal awakenings, respectively. Thus, measures of diurnal and nocturnal motor activity and immobility appear useful for the objective assessment of some of the sleep-wakefulness manifestations of narcolepsy.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1469-8986.1995.tb02957.x

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Digitale Medien

The Influence of Branched Polypeptide Carriers on the Immunogenicity of Predicted Epitopes of HSV-1 Glycoprotein D (1994)

HILBERT, Á. ; HUDECZ, F. ; MEZÔ, G. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of immunology 40 (1994), S. 0

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ISSN: 1365-3083

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: To investigate the role of synthetic polypeptide carriers in inducing an epitope-specific immune response relevant for vaccine design, peptides comprising two distinct regions of herpes simplex virus type I glycoprotein D (1–23 and 273–284) have been conjugated to the branched polypeptides with polylysine backbone, poly[L-Lys-(DL-Alam)] (AK), or poly[L-Lys-(LeUi-DL-Alam)] (LAK) and to keyhole limpet haemocyanin (KLH). The magnitude, fine specificity and isotype distribution of the conjugate-, peptide and carrier-specific antibody responses were characterized in immunized BALB/c and CBA mice. Conjugates containing the polypeptide carrier AK were the most effective in inducing HSV gD-peptide specific antibody responses while KLH peptide conjugates resulted in conjugate-specific antibody responses without measurable peptide specificity. The efficacy of AK-peptide conjugates was verified by the dominant appearance of peptide-specific antibodies belonging to functionally efficient IgG isotopes, accompanied by low levels of carrier specific antibody responses. Preimmunization of BALB/ or CBA mice with AK conjugates comprising the 1–23 or 276–284 HSV peptides resulted in prolonged survival of animals infected with a lethal dose of infectious HSV-1. The potency of these conjugates in eliciting a protective immune response shows a close correlation with the relative levels of conjugate-induced virus specific antibodies and the neutralizing activity of sera as measured in preimmunized survivors.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03512.x

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