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  • 1
    Digitale Medien
    Digitale Medien
    Potassium Channels Underlying The Resting Potential Of Pulmonary Artery Smooth Muscle Cells (2002)
    Melbourne, Australia : Blackwell Science Asia Pty. Ltd.
    Clinical and experimental pharmacology and physiology 29 (2002), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The molecular identity of the K channels giving rise to the negative membrane potential of pulmonary artery smooth muscle cells has yet to be determined.2. To date, most studies have focused on voltage-gated, delayed rectifier channels and their roles in mediating hypoxia-induced membrane depolarization. There is, however, strong evidence that an outwardly rectifying K+ conductance distinct from the classical delayed rectifier is involved.3. Growing evidence that TASK-like channels can sense hypoxia and are present in pulmonary artery smooth muscle cells suggests that they may be responsible for the resting K+ conductance and resting potential.4. The present review considers the evidence that particular K channels maintain the resting membrane potential of pulmonary artery smooth muscle cells and mediate the depolarizing response to hypoxia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1440-1681.2002.03653.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Metal ion-induced permeability changes in cell membranes: A minireview (1994)
    Springer
    Cellular and molecular neurobiology 14 (1994), S. 781-789 
    Details
    ISSN: 1573-6830
    Schlagwort(e): excitable membrane ; ionic channel ; heavy metal ; metal ion-induced current
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary 1. The paper summarizes the effects of the metal ions Cu2+, Pb2+, Ag+, Hg2+, Zn2+, and Cd2+ applied externally or internally to the surface membrane of different excitable cells. 2. Conductance changes induced by metal ions, and metal ion-activated current, are compared with respect to their ion and voltage dependence. 3. It is suggested that metal ion-induced effects can be realized through special structures of the cell membrane, the metal ion “receptors,” although other mechanisms, as, for example, competition for Ca-binding sites in the channel forming proteins, cannot be excluded.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02088684
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    A study of the connection between the interneuron initiating pacemaker activity in a bursting neuron and the bursting neuron of the snailHelix pomatia (1986)
    Springer
    Cellular and molecular neurobiology 6 (1986), S. 177-190 
    Details
    ISSN: 1573-6830
    Schlagwort(e): bursting neuron ; interneuron ; Helix snail ; slow inward current
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary 1. The connection between an interneuron initiating pacemaker activity in the bursting RPa1 neuron and the bursting neuron itself (Pin and Gola, 1983) has been analyzed in the snailHelix pomatia. 2. Prolonged depolarization of the interneuronal membrane produced in it a series of action potentials as well as a parallel initiation or enhancement of bursting activity in the RPa1 neuron. 3. If the discharge in the interneuron was evoked by short current pulses of threshold amplitude, no bursting activity was seen in the RPa1 neuron. However, short stimuli delivered on the background of subthreshold depolarization of the interneuronal membrane produced bursting activity in the RPa1 neuron. 4. Under voltage-clamp conditions a slow inward current could be recorded in the RPa1 neuronal membrane after stimulation of the interneuron with a latency of about 2 sec. Short shifts of the holding potential in the hyperpolarizing direction at the maximum of this current produced a transient outward current. 5. Replacement of extracellular Ca2+ by Mg2+ ions, as well as addition of 1 mM CdCl2 to the external solution, prevented the response to the interneuronal stimulation in the RPa1 neuron. 6. Electron microscopic investigation of the interneuron has shown the abundance of Golgi complexes in its cytoplasm with electron-dense granules in their vicinity. 7. It is concluded that the connection between the interneuron and the bursting neuron is of chemical origin, based on secretion by the former of some substances which activate at least two types of ionic channels in the membrane of the RPa1 neuron.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00711069
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