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  • 1
    Digitale Medien
    Digitale Medien
    Early activation of cutaneous vessels and epithelial cells is characteristic of acute systemic onset juvenile idiopathic arthritis (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Experimental dermatology 14 (2005), S. 0 
    Details
    ISSN: 1600-0625
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract:  In biopsies of 16 patients (mean: 5.2 years) with acute systemic onset juvenile idiopathic arthritis (SOJIA), we analysed the initial cellular events during the characteristic cutaneous rash for composition of the infiltrate and for expression of activation markers on epithelial and endothelial cells. Despite the fleeting nature of the rash, there was a characteristic infiltration of neutrophils and monocytes, accompanied by a marked expression of endothelial adhesion receptors. In addition, we found a general activation of the cutaneous epithelium reflected by the expression of the pro-inflammatory S100-proteins – myeloid-related protein 8 (MRP8) and MRP14. In responders to therapy, follow-up biopsies showed a complete normalization of these inflammatory parameters, whereas non-responders presented with continuous signs of activation. In conjunction with the high level of epithelial activation, we detected an infiltrate of leucocytes within epithelium of sweat gland ducts during active SOJIA. Such a pattern has not been described for other inflammatory skin diseases nor did we find it in biopsies from nine patients with acute urticaria. It was accompanied by exclusive expression of MRP8, but not MRP14 by the secretory cells of sweat glands. Because MRP8 and MRP14, released by epithelial cells, exhibit pro-inflammatory effects on endothelial cells and leucocytes, the particular expression pattern of MRP8 and MRP14 in SOJIA is likely to represent a decisive early constitutive component in this inflammatory disease. Their differential expression further points to distinct roles of the individual molecules in inflammatory processes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.0906-6705.2005.00271.x
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  • 2
    Digitale Medien
    Digitale Medien
    Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock (2007)
    [s.l.] : Nature Publishing Group
    Nature medicine 13 (2007), S. 1042-1049 
    Details
    ISSN: 1546-170X
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] To identify new components that regulate the inflammatory cascade during sepsis, we characterized the functions of myeloid-related protein-8 (Mrp8, S100A8) and myeloid-related protein-14 (Mrp14, S100A9), two abundant cytoplasmic proteins of phagocytes. We now demonstrate that mice lacking ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/nm1638
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  • 3
    Digitale Medien
    Digitale Medien
    Endovascular treatment of traumatic arterio-venous fistulas of the vertebral artery (1993)
    Springer
    Neurosurgical review 16 (1993), S. 267-273 
    Details
    ISSN: 1437-2320
    Schlagwort(e): Arterio-venous malformation ; detachable balloon technique embolization ; vertebral artery fistula
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Cervical vertebral artery fistulas are rare arteriovenous malformations between the vertebral artery and veins of the neighbourhood. The etiology of the fistulas may be traumatic or spontaneous. Management and the results in two patients with large arterio-venous fistulas of the cervical vertebral artery with severe deterioration of spinal function by using the detachable balloon technique are discussed. Complete angiographic and clinical cure was achieved in both patients and no complications related to the embolization procedure occured. The detachable balloon technique is an effective method for selective occlusion of the fistula. Good radiographic monitoring facilities are required to make endovascular procedures effective and safe.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00383833
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  • 4
    Digitale Medien
    Digitale Medien
    Die Rolle der Radiologie in der Diagnostik und Therapie des zentralen Gallengangskarzinoms (1999)
    Springer
    Der Onkologe 5 (1999), S. 499-505 
    Details
    ISSN: 1433-0415
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Untersuchungsverfahren der diagnostischen und interventionellen Radiologie beruhen auf dem Einsatz der farbkodierten und kontrastverstärkten Dopplersonographie, der Spiral-Computertomographie, der Magnetresonanzverfahren (MR), wie der MR-Tomographie (MRT) und MR-Cholangio-Pankreatikographie (MRCP), sowie der perkutanen Cholangiographie (PTC). Interventionelle Verfahren mit therapeutischer Option beinhalten den Einsatz der PTCD (Drainage), sowie angiographischer Verfahren mit Embolisationstechniken zur Induktion einer Leberregeneration. Die moderne bildgebende Diagnostik erlaubt die exakte Bestimmung der Höhe der Obstruktion und der Ausdehnung des Tumors entlang der intrahepatischen Gallenwege. Mit der MRCP gelingt der Nachweis einer malignen Gallenwegsstenose mit einer Sensitivität von 86% und einer Spezifität von 98%, wobei die korrekte Klassifikation der Läsion als maligne in 50–80% der Fälle gelingt. Die moderne MR-Technologie der MRT mit MRCP stellt die optimale bildgebende diagnostische Strategie zur Abklärung zentraler Gallengangskarzinome dar, ergänzt durch die invasive ERC und in Einzelfällen durch die PTC. Interventionelle Embolisationstechniken zur Leberregeneration erhöhen den Anteil primär kurativ reserzierbarer Patienten.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007610050391
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  • 5
    Digitale Medien
    Digitale Medien
    Book reviews (1992)
    Springer
    European radiology 2 (1992), S. 277-277 
    Details
    ISSN: 1432-1084
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00595846
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  • 6
    Digitale Medien
    Digitale Medien
    Associative learning in a network model of Hermissenda crassicornis (1993)
    Springer
    Biological cybernetics 69 (1993), S. 19-28 
    Details
    ISSN: 1432-0770
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Informatik , Physik
    Notizen: Abstract A companion paper in a previous issue of this journal presented a resistance-capacitance circuit computer model of the four-neuron visual-vestibular network of the invertebrate marine mollusk Hermissenda crassicornis. In the present paper, we demonstrate that changes in the model's output in response to simulated associative training is quantitatively similar to behavioral and electrophysiological changes in response to associative training of Hermissenda crassicornis. Specifically, the model demonstrates many characteristics of conditioning: sensitivity to stimulus contingency, stimulus specificity, extinction, and savings. The model's learning features also are shown to be devoid of non-associative components. Thus, this computational model is an excellent tool for examining the information flow and dynamics of biological associative learning and for uncovering insights concerning associative learning, memory, and recall that can be applied to the development of artificial neural networks.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00201405
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  • 7
    Digitale Medien
    Digitale Medien
    Associative learning in a network model of Hermissenda crassicornis (1993)
    Springer
    Biological cybernetics 70 (1993), S. 95-95 
    Details
    ISSN: 1432-0770
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Informatik , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00202571
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  • 8
    Digitale Medien
    Digitale Medien
    Associative learning in a network model of Hermissenda crassicornis (1992)
    Springer
    Biological cybernetics 68 (1992), S. 125-133 
    Details
    ISSN: 1432-0770
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Informatik , Physik
    Notizen: Abstract A time-varying Resistance-Capacitance (RC) circuit computer model was constructed based on known membrane and synaptic properties of the visualvestibular network of the marine snail Hermissenda crassicornis. Specific biophysical properties and synaptic connections of identified neurons are represented as lumped parameters (circuit elements) in the model; in the computer simulation, differential equations are approximated by difference equations. The model's output, membrane potential, an indirect measure of firing frequency, closely parallels the behavioral and electrophysiologic outputs of Hermissenda in response to the same input stimuli presented during and after associative learning. The parallelism of the computer modeled and the biologic outputs suggests that the model captures the features necessary and sufficient for associative learning.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00201434
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  • 9
    Digitale Medien
    Digitale Medien
    Pulmonary sling: Morphological findings. Pre- and postoperative course (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 2-14 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Pulmonary sling ; LPA variants ; Tracheobronchial angles ; Tracheal resection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Pulmonary sling (PS) is a congenital condition in which the left pulmonary artery (LPA) arises from the right pulmonary artery (RPA), forming a sling around the trachea causing tracheal compression. The incidence is not so rare as initially thought. Symptoms of severe airway obstruction often begin in the newborn or young infant. Echo-colour-Doppler may reveal the PS but emphysema can mask the typical findings. Deviation of fluid-filled lungs may be detected prenatally. Chest radiographs show unusual air distribution, deviation of heart and mediastinum and altered tracheobronchial angles. Bronchography and bronchoscopy demonstrate the high incidence of associated tracheal anomalies such as cartilagenous rings and long tracheal stenosis. Anterior oesophageal indentation is not always seen in the oesophogram. Magnetic resonance imaging (MRI) and computed tomography (CT) reveal the PS, but cautious interpretation is necessary because of different levels of the anomalous LPA. PS and associated cardiovascular malformations can be clearly detected by angiography. Associated extrathoracic anomalies are common. Early diagnosis and therapy of PS is mandatory and consists of reimplantation of the LPA into the pulmonary trunk and division of the ligamentum arteriosum. The postoperative course may be cumbersome necessitating bronchological interventions. Tracheal resection may be necessary but restenosis is frequent. A one-stage repair has been proposed in such cases and was successfully done in a few reported cases. Relief of respiratory obstruction is often complete when there are no associated tracheobronchial anomalies. Late postoperative course is favourable but respiratory obstructive attacks may occur with decreasing incidence over time and tracheal growth.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01972965
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  • 10
    Digitale Medien
    Digitale Medien
    Pulmonary sling: morphological findings. Pre- and postoperative course (1994)
    Springer
    European journal of pediatrics 154 (1994), S. 2-14 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Key words     Pulmonary sling ; LPA variants ; Tracheobronchial angles ; Tracheal resection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract      Pulmonary sling (PS) is a congenital condition in which the left pulmonary artery (LPA) arises from the right pulmonary artery (RPA), forming a sling around the trachea causing tracheal compression. The incidence is not so rare as initially thought. Symptoms of severe airway obstruction often begin in the newborn or young infant. Echo-colour-Doppler may reveal the PS but emphysema can mask the typical findings. Deviation of fluid-filled lungs may be detected prenatally. Chest radiographs show unusual air distribution, deviation of heart and mediastinum and altered tracheobronchial angles. Bronchography and bronchoscopy demonstrate the high incidence of associated tracheal anomalies such as cartilagenous rings and long tracheal stenosis. Anterior oesophageal indentation is not always seen in the oesophogram. Magnetic resonance imaging (MRI) and computed tomography (CT) reveal the PS, but cautious interpretation is necessary because of different levels of the anomalous LPA. PS and associated cardiovascular malformations can be clearly detected by angiography. Associated extrathoracic anomalies are common. Early diagnosis and therapy of PS is mandatory and consists of reimplantation of the LPA into the pulmonary trunk and division of the ligamentum arteriosum. The postoperative course may be cumbersome necessitating bronchological interventions. Tracheal resection may be necessary but restenosis is frequent. A one-stage repair has been proposed in such cases and was successfully done in a few reported cases. Relief of respiratory obstruction is often complete when there are no associated tracheobronchial anomalies. Late postoperative course is favourable but respiratory obstructive attacks may occur with decreasing incidence over time and tracheal growth.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01972965
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