ISSN:
1432-069X
Keywords:
Key words T cells
;
Homing receptor
;
Streptococci
;
Psoriasis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The cutaneous lymphocyte-associated antigen (CLA) has been proposed as a homing receptor for the selective migration of memory T cells into the skin. To investigate the effect of group A streptococci (GAS) on the migration of T cells in psoriasis, CLA expression was assessed by double-staining for CD3 and the HECA-452 epitope on peripheral blood T cells from 13 patients with psoriasis, 10 patients with other inflammatory skin diseases and 12 normal controls before and after 7 days culture with a GAS sonicate, Candida albicans (control antigen) or medium. In addition, CLA+, and CLA–, CD3+ CD45RO+ subsets were isolated from individuals in each group and V β2 expression and proliferation to GAS studied. Mean CLA expression by freshly isolated T cells was almost identical in the three groups. After culture with GAS, T cells from the psoriatic patients and control groups showed a significant increase in mean percentage CLA + expression compared to medium ( P 〈 0.002, P 〈 0.05, respectively). This induction was inhibited by the addition of anti-IL-12 antibody. However, in psoriatic patients, but not in controls, the GAS-induced increase was significantly greater than that of C. albicans ( P 〈 0.002) and was accompanied by a decrease in T cells positive for the peripheral lymph node homing receptor, L-selectin ( P 〈 0.05). The percentage of Vβ2 + T cells was markedly higher in the CLA + than in the CLA – T-cell subset in psoriatic patients ( P 〈 0.01) and controls; both subsets proliferated to GAS, in each group. These findings suggest a differential modulation of specific tissue homing receptors on T cells by GAS in psoriasis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004030050260
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