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  • 11
    Electronic Resource
    Electronic Resource
    MRI in radiation-induced myelopathy and pharyngocutaneous fistula (1996)
    Springer
    Neuroradiology 38 (1996), S. S130 
    Details
    ISSN: 1432-1920
    Keywords: Radiation-induced myelopathy ; Pharyngocutaneous fistula ; Spinal cord ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient developed a cervical myelopathy 20 months after radiotherapy for a carcinoma of the larynx. MRI showed an intramedullary lesion at C7. Although radiation myelopathy was suspected, tumour recurrence could not be excluded. A radiation-induced pharyngocutaneous fistula, confirmed histologically, appeared a month later. The fistula lay just anterior to the level of the spinal cord lesion, a finding useful in supporting a diagnosis of simultaneous radiation myelopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02278140
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  • 12
    Electronic Resource
    Electronic Resource
    Intronic GAA triplet repeat expansion in Friedreich’s ataxia presenting with pure sensory ataxia (1997)
    Springer
    Journal of neurology 244 (1997), S. 390-391 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050109
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  • 13
    Electronic Resource
    Electronic Resource
    An early description of striatonigral degeneration (1999)
    Springer
    Journal of neurology 246 (1999), S. 462-466 
    Details
    ISSN: 1432-1459
    Keywords: Key words. Olivopontocerebellar ; atrophy ; Striatonigral degeneration ; Parkinson’s disease ; Huntington’s ; disease ; Pick’s disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our aim was to revisit the papers published by Scherer 1933 describing four cases of sporadic olivopontocerebellar atrophy (OPCA) thought to represent the earliest description of striatonigral degeneration. One should note that extrapyramidal rigidity associated with OPCA was then considered a type of cerebellar parkinsonism. Two of Scherer’s four patients had severe parkinsonism masking cerebellar signs. Pathologically both cases displayed marked degeneration of the striatum and nigra and partially developed pontocerebellar atrophy. Cerebellar ataxia was the outstanding feature in the other two, their pathological study showing severe pontocerebellar lesions and incipient striatonigral atrophy. Scherer stated that the severity of parkinsonism in OPCA is not correlated with the degree of cerebellar degeneration but with that of striatum and nigra. We conclude that Scherer gave the first accurate description of striatonigral degeneration. Moreover, his contribution was essential in ruling out the prevalent notion of cerebellar parkinsonism in OPCA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050384
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  • 14
    Electronic Resource
    Electronic Resource
    Isolated unilateral hypoglossal nerve palsy: nine cases (1998)
    Springer
    Journal of neurology 245 (1998), S. 98-100 
    Details
    ISSN: 1432-1459
    Keywords: Key words Hypoglossal nerve ; palsy ; Cranial mononeuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report nine patients with hypoglossal nerve palsy as the sole neurological manifestation, without simultaneous involvement of other cranial nerves or long-tract signs. In four patients, no cause was found and the outcome was excellent. The next common cause proved to be metastatic disease at the base of the skull in three patients. Two exceptional causes were Chiari malformation in one case and dural arteriovenous fistula of the transverse sinus in another. Although the aetiological importance and ominous prognosis of neoplasia has been emphasized by others, our study suggests that an isolated hypoglossal nerve palsy may be benign and idiopathic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050185
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  • 15
    Electronic Resource
    Electronic Resource
    Brain-stem auditory evoked potentials and blink reflex in friedreich's ataxia (1991)
    Springer
    Journal of neurology 238 (1991), S. 212-216 
    Details
    ISSN: 1432-1459
    Keywords: Friedreich's ataxia ; Brain-stem auditory evoked potentials ; Blink reflex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The brain-stem involvement in Friedreich's ataxia (FA) was studied by using brain-stem auditory evoked potentials (BAEPs) and the blink reflex. Ten out of 18 patients had abnormal BAEPs, the main abnormality being complete absence of responses and disappearance of wave V. Combined degeneration of the peripheral and central acoustic pathways probably accounts for these findings. The blink reflex was abnormal in 50% of the cases. The outstanding abnormality was bilateral delay of late responses with normal early response, which could be correlated with the known pallor of the descending trigeminal tracts. In contrast with BAEP findings, blink reflex abnormalities did not correlate with either the age of patients or the severity and duration of the disease. These data suggest a difference in susceptibility to degeneration between the auditory system and neuronal system subserving the blink reflex. We conclude that systematic BAEP and blink reflex recording is useful in the electrophysiological evaluation of FA patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314783
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  • 16
    Electronic Resource
    Electronic Resource
    An early description of striatonigral degeneration: reply to Drs Jellinger and Wenning (2000)
    Springer
    Journal of neurology 247 (2000), S. 311-312 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050592
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  • 17
    Electronic Resource
    Electronic Resource
    Adrenergic receptors in the cerebellum of olivopontocerebellar atrophy (1994)
    Springer
    Journal of neural transmission 96 (1994), S. 135-142 
    Details
    ISSN: 1435-1463
    Keywords: Alpha2-adrenoceptors ; autoradiography ; β-adrenoceptors ; 3H-bromoxidine ; 125I-iodocynaopindolol ; cerebellum ; olivopontocerebellar atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using autoradiographic techniques we studied the changes that in adrenergic receptors occurred in the cerebellum of two olivopontocerebellar atrophy (OPCA) patients as compared with a control group. In OPCA cerebellum the densities of total β-adrenoceptors were reduced along the cortex but increased in the white matter. Although mainly the β1 subtype was decreased along the cerebellar cortex, the increase of β-receptors over the white matter was due to a selective raise in the β2 subtype. These findings suggest a post-synaptic neuronal location for the β1 subtype and a glial location for the β2-adrenoceptor. On the other hand, alpha2-adrenoceptors were clearly reduced all along the cerebellar cortex of these OPCA brains, this probably being secondary to the loss of presynaptic adrenergic terminals arising from the locus coeruleus. These results help clarify both the subcellular location of adrenoceptors in human cerebellum and the neurochemical pathophysiology of OPCA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277935
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