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  • 11
    Electronic Resource
    Electronic Resource
    Time course of the pharmacological response to beta-lactam antibiotics in vitro and in vivo (1984)
    Springer
    European journal of clinical microbiology & infectious diseases 3 (1984), S. 592-597 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experimental examples of different beta-lactam-organism combinations in vitro and in vivo are presented to demonstrate that a rationale for dosage regimens of antibiotics should not be based solely on pharmacokinetic parameters. The time course of the pharmacological response (onset and speed of bacterial killing) and the presence or absence of a postantibiotic effect must also be considered. Such pertinent information can be derived from in vitro studies such as time-kill curves and regrowth curves of bacteria obtained at and after short exposure of the target organisms to various concentrations of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013630
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