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  • 11
    Electronic Resource
    Electronic Resource
    Colchicine in avian sodium urate and calcium pyrophosphate microcrystal arthritis (1973)
    Springer
    Inflammation research 3 (1973), S. 20-23 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of single doses of colchicine on the acute arthritis elicited by the injection of microcrystalline sodium urate, calcium pyrophosphate or talcum into one intertarsal joint of chickens was functionally assessed. Colchicine was significantly active against the urate challenge. The arthritic inflammation induced by calcium pyrophosphate or talcum was reduced to a lesser degree. Colchicine may thus particularly affect inflammatory processes related to urate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02023846
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  • 12
    Electronic Resource
    Electronic Resource
    Cytotoxic drugs in an avian urate microcrystal arthritis (1973)
    Springer
    Inflammation research 3 (1973), S. 24-27 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of single doses of cytotoxic drugs on the acute arthritis elicited by the injection of microcrystalline sodium urate into one intertarsal joint of pigeons or chickens was functionally assessed. Procarbazine and actinomycin D were effective while no inhibition was provided by cyclophosphamide, methotrexate, cytosine arabinoside, 6-mercaptopurine, vinblastine, vincristine and BCNU. It is suggested that within the anti-inflammatory repertoire displayed by antiproliferative agents, distinctive properties leading to particular interference with cellular performance might be exploited for selected therapeutic indications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02023847
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  • 13
    Electronic Resource
    Electronic Resource
    The avian microcrystal arthritis II. Central versus peripheral effects of sodium salicylate, acetaminophen and colchicine (1974)
    Springer
    Inflammation research 4 (1974), S. 27-33 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An acute inflammation was elicited in pigeons by the injection of urate crystals (UC) into the intertarsal joint. From the resulting inflammation two parameters were recorded simultaneously: temperature-rise in the inflamed tissue and nociception, a correlate of pain. The effects of sodium salicylate, acetaminophen and colchicine on both parameters were investigated. All reduced nociception when administered at appropriate times and in suitable doses. However, only colchicine prevented temperaturerise in the inflamed area. After the injection of sodium salicylate an increase in temperature was also seen in noninflamed control tissue. Acetaminophen did not produce this effect. From these results it is concluded that colchicine acts peripherally at the site of inflammation whilst acetaminophen acts primarily, on nociception leaving local events at the site of inflammation unimpaired. For sodium salicylate a peripheral effect cannot be ruled out. The temperature effect of this drug appears to be of interest for the understanding of its antipyretic action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965489
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  • 14
    Electronic Resource
    Electronic Resource
    The avian microcrystal arthritis IV. The impact of sodium salicylate, acetaminophen and colchicine on leukocyte invasion and enzyme liberation in vivo (1974)
    Springer
    Inflammation research 4 (1974), S. 101-107 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The impact of sodium salicylate, acetaminophen and colchicine on leukocyte accumulation and the release of certain enzymes at the site of inflammation were investigated. Sodium salicylate slightly increased leukocyte accumulation and enzyme-release at early stages and decreased enzymerelease at later stages of the inflammation period measured. Similar effects were seen with acetaminophen. In contrast, colchicine significantly inhibited the accumulation of leukocytes and to an even greater extent the enzyme-release from lysosomes. It was most effective in this respect, when applied before eliciting the inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966818
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  • 15
    Electronic Resource
    Electronic Resource
    The avian microcrystal arthritis III. invasion and enzyme-release from leukocytes at the site of inflammation (1974)
    Springer
    Inflammation research 4 (1974), S. 95-100 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An attempt was made to find a suitable parameter for the cellular events taking place at the site of inflammation of the avian microcrystal arthritis. For that purpose, the arthritis elicited by injections of urate crystals (UC) in pigeons was adopted for chicken. In the larger animals it was possible to obtain sufficient joint fluid for histological and biochemical investigation. In order to find a parameter specific for the UC arthritis, the histological and biochemical findings were compared with the time-course of nociception and temperature-rise of the inflammed joints and with results from animals having received intra-articular injections of Latex particles (LP). It was found that UC-injections cause an inflammation in intertarsal joints of chicken. Nociception and temperaturerise as parameters of this inflammation show similar time-courses as described for pigeons [4]. LP-injections also caused moderate signs of inflammation. They appeared later and only in some animals. However, the time-course of appearance of polymorphonuclear leukocytes (PMN) and lysozyme in the joint fluid was the same in UC-and LP-treated animals. Only beta-glucuronidase-activity was found to reflect the other two parameters of inflammation. From the results it is concluded that the beta-glucuronidase activity in the joint fluids might be used as an enzymatic parameter of this inflammation. In addition, doubts are raised against the proposed mediator function of PMN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966817
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  • 16
    Electronic Resource
    Electronic Resource
    The avian microcrystal arthritis II. Central versus peripheral effects of sodium salicylate, acetaminophen and colchicine (1994)
    Springer
    Inflammation research 43 (1994), S. 211-217 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An acute inflammation was elicited in pigeons by the injection of urate crystals (UC) into the intertarsal joint. From the resulting inflammation two parameters were recorded simultaneously: temperature-rise in the inflamed tissue and nociception, a correlate of pain. The effects of sodium salicylate, acetaminophen and colchicine on both parameters were investigated. All reduced nociception when administered at appropriate times and in suitable doses. However, only colchicine prevented temperature-rise in the inflamed area. After the injection of sodium salicylate an increase in temperature was also seen in non-inflamed control tissue. Acetaminophen did not produce this effect. From these results it is concluded that colchicine acts peripherally at the site of inflammation whilst acetaminophen acts primarily on nociception leaving local events at the site of inflammation unimpaired. For sodium salicylate a neripheral effect cannot be ruled out. The temperature effect of this drug appears to be of interest for the understanding of its antipyretic action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986691
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  • 17
    Electronic Resource
    Electronic Resource
    How aspirin might work: A pharmacokinetic approach (1994)
    Springer
    Inflammation research 43 (1994), S. 218-220 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A pharmacokinetic interpretation of the effects and side-effects of acidic non-steroid anti-inflammatory drugs is presented. It is based on the general principles of drug action and leads to the conclusion that aspirin-like drugs should specifically accumulate and exert pharmacological activity in inflammed tissue, stomach and kidney. Therefore the common effects and side-effects of these drugs may result from unspecific effects in these compartments and might not necessarily be due to specific, i.e., receptor mediated action(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986692
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  • 18
    Electronic Resource
    Electronic Resource
    How aspirin might work: A pharmacokinetic approach (1974)
    Springer
    Inflammation research 4 (1974), S. 230-232 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A pharmacokinetic interpretation of the effects and side-effects of acidic non-steroid anti-inflammatory drugs is presented. It is based on the general principles of drug action and leads to the conclusion that aspirin-like drugs should specifically accumulate and exert pharmacological activity in inflammed tissue, stomach and kidney. There-fore the common effects and side-effects of these drugs may result from unspecific effects in these compartments and might not necessarily be due to specific, i.e., receptor mediated action(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965225
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  • 19
    Electronic Resource
    Electronic Resource
    HEPES-buffered media may induce prostaglandin release from macrophages in tissue culture (1980)
    Springer
    Inflammation research 10 (1980), S. 491-492 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract On investigating the release of PGE2 from mouse peritoneal macrophages in tissue culture it was found that the spontaneous release of PGE2 was dependent on the culture conditions employed. The type of buffering of the medium was especially important. Using CO2-sodium bicarbonate buffers we observed little, if any, spontaneous release of prostaglandins (PGs) from macrophages, whereas in the presence ofN-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid (HEPES) buffer in some cases a dramatic increase in PG release was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024147
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  • 20
    Electronic Resource
    Electronic Resource
    Non-acidic pyrazoles: Inhibition of prostaglandin production, carrageenan oedema and yeast fever (1983)
    Springer
    Inflammation research 13 (1983), S. 360-363 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prostaglandin production from mouse peritoneal macrophages was elicited by the tumour promotor 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The inhibitory potency (IC50) of metamizole and its major metabolites as well as other non-acidic pyrazoles was defined in this system. A reliable IC50-value could not be assigned to metamizole. Isopropylaminophenazone was as active as acetylsalicylic acid while aminophenazone and methylaminophenazone, the major metabolites of metamizole, were about 10 times and phenazone 100 times less potent than acetylsalicylic acid, The major excretion products of metamizole, 4-formyl- and 4-acetyl-aminophenazone were inactive. The IC50-values obtained agree with those necessary for manifestation of anti-inflammatory effects in rats but are up to 10 times higher than those measurable in human plasma after administration of analgesic-antipyretic doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971489
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