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  • 11
    Electronic Resource
    Electronic Resource
    Synaptic vesicle cytochemistry changes when cultured sympathetic neurones develop cholinergic interactions (1976)
    [s.l.] : Nature Publishing Group
    Nature 262 (1976), S. 308-310 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We established sympathetic neuronal networks by dissociating the SCG from perinatal rats by a method previously described9, but without antimitotic agents to suppress non-neuronal cell growth. In these conditions a substantial number of non-neuronal cells are present although these do not develop ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/262308a0
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  • 12
    Electronic Resource
    Electronic Resource
    Evidence that sensory axons are mitogenic for Schwann cells (1975)
    [s.l.] : Nature Publishing Group
    Nature 256 (1975), S. 662-664 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Tissue culture techniques utilised in obtaining separation of these two components from the rat peripheral nervous system will be reported in detail elsewhere. Briefly, to obtain Schwann cells, rat dorsal root ganglia (DRG) obtained just before birth were stripped of their capsule and after ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/256662a0
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  • 13
    Electronic Resource
    Electronic Resource
    Schwann Cell Proliferation In Vitro (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 486 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb48072.x
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  • 14
    Electronic Resource
    Electronic Resource
    Linkage between Schwann Cell Extracellular Matrix Production and Ensheathment Function (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 486 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb48077.x
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  • 15
    Electronic Resource
    Electronic Resource
    Die Endigungen der Nerven in der Haut des Frosches (1892)
    Springer
    Anatomy and embryology 2 (1892), S. 173-203 
    Details
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02302981
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  • 16
    Electronic Resource
    Electronic Resource
    Development of cholinergic characteristics in adrenergic neurones is age dependent (1977)
    [s.l.] : Nature Publishing Group
    Nature 267 (1977), S. 536-539 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] These experiments were made possible by two developments. First, small explants of superior cervical ganglia (SCG) were successfully cultured from increasingly older rats, including adult. A similar pattern of ChAc development was seen in SCG from perinatal rats regardless of whether explants or ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/267536a0
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  • 17
    Electronic Resource
    Electronic Resource
    Evidence that axons are mitogenic for oligodendrocytes isolated from adult animals (1986)
    [s.l.] : Nature Publishing Group
    Nature 320 (1986), S. 756-758 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Experiments were constructed by adding suspensions of dissociated adult spinal cord cells to pure cultures of dissociated dorsal root ganglion neurones prepared as described previously7. At the time of addition of the CNS glial cells, these cultures consisted of a large, centrally located, loosely ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/320756a0
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  • 18
    Electronic Resource
    Electronic Resource
    The role of the Schwann cell in trophic support and regeneration (1994)
    Springer
    Journal of neurology 242 (1994), S. S19 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Schwann cells show remarkable versatility in undertaking a broad repertoire of functions. Ensheathment and myelination are specifically regulated by contact with axons, and the Schwann cell is centrally. involved in extracellular matrix production in the peripheral nerve trunk. Additional Schwann cell functions include the promotion of both peripheral and central nervous system regeneration, provision of a versatile source of trophic factors, the capacity to remyelinate central nervous system axons, and the restoration of electrophysiological conduction. Since it is now possible to isolate Schwann cells both from neonatal and adult human peripheral nerve, their ability to promote regenerative efforts by many central neurons suggests a role for Schwann cell autografts in influencing central nervous system repair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00939235
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  • 19
    Electronic Resource
    Electronic Resource
    Basal lamina-associated heparan sulphate proteoglycan in the rat PNS: Characterization and localization using monoclonal antibodies (1986)
    Springer
    Journal of neurocytology 15 (1986), S. 37-51 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cultured rat Schwann cells produce a basal lamina (BL)-associated heparan sulphate proteoglycan (HSPG). The HSPG has an apparent molecular weight of 〉450 kD, is sensitive to both heparinase and heparitinase and contains a core protein of ∼400kD. Two independently derived monoclonal antibodies, B3 and C17, recognize this HSPG. Using B3 and C17, we found that this HSPG, or immunologically related material, is present in BLs throughout the body and in a small number of connective tissue sites without a formed BL. In the PNS it is present in BLs of Schwann cell-axon units, in synaptic and extrasynaptic portions of muscle fibre BL, and in the BLs of satellite cells that ensheath neurons in sympathetic and sensory ganglia. This HSPG is not detectable in the neuropil of the brain and spinal cord. Neurons, Schwann cells and fibroblasts cultured alone do not assemble a BL or accumulate immunocytochemically detectable amounts of this HSPG, but it is present in BLs assembled in myotube and in Schwann cell-neuron cultures. Thus, this HSPG is a component of most, if not all, BLs in the PNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02057903
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  • 20
    Electronic Resource
    Electronic Resource
    Comparison of the Schwann cell surface and Schwann cell extracellular matrix as promoters of neurite growth (1987)
    Springer
    Journal of neurocytology 16 (1987), S. 539-555 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ability of Schwann cells to influence the direction and rate of neurite growth was investigated in a tissue culture model of the bands of Büngner of injured peripheral nerve. The arrangement of this culture system allowed testing of the growth-promoting properties of the Schwann cell surface and extracellular matrix (ECM) assembled by Schwann cells rather than soluble substances secreted into conditioned medium. Various components of peripheral nerve were examined separately as substrata for regenerating neuntes: (i) Schwann cells and their ECM; (ii) Schwann cells alone; (iii) Schwann cell ECM alone; (iv) Schwann cells, fibroblasts, and their assembled ECM; (v) Schwann cells, their ECM and neurites; and (vi) purified laminin. Regenerating peripheral neurites were from expiants of foetal rat dorsal root ganglia, which had been cultured for several weeks to rid them of accompanying non-neuronal cells, or from expiants of foetal rat superior cervical ganglia, which contained non-neuronal cells. CNS neurites from the somatosensory cortex of embryonic rats were also studied; these neurites may be either first growing or regenerating. Neurites from all types of expiants studied grew longer and were guided on a substratum of Schwann cells or Schwann cell ECM compared with a collagen substratum. The presence of fibroblasts during ECM assembly did not enhance the neurite growth-promoting activity. The design of the experiments suggested that the factors by which the Schwann cells or their ECM promoted and guided neurite outgrowth were surface-bound rather than medium-borne. Electron microscopic examination showed that neurites grew on either Schwann cell surfaces or basal lamina material. Attempts to define the chemical nature of the neurite growth-promoting effect of ECM by partial enzymatic digestion did not identify any single component as essential. Purified laminin was a more effective promoter of outgrowth of peripheral neurites than were Schwann cells or Schwann cell ECM. Cortical expiants also grew on laminin, but neurites were accompanied on this substratum by a massive migration of non-neuronal cells; the neurites appeared to extend primarily on the non-neuronal cells rather than by direct attachment to the laminin substratum. This characteristic outgrowth of cortical non-neuronal cells on laminin was not consistently seen on Schwann cell ECM. In conclusion, either the Schwann cell surface or the ECM produced and assembled by Schwann cells promotes neurite outgrowth and guides that outgrowth from the several types of peripheral and CNS neurons studied in this report.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01668507
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