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  • 11
    Electronic Resource
    Electronic Resource
    DNA polymorphism of the C2 locus (1985)
    Springer
    Immunogenetics 22 (1985), S. 377-390 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The extent of the C2 locus in the HLA class III region has been determined by Southern blotting techniques and by DNA sequence analysis. The gene is 18 kb in length and therefore provides a marked contrast to the adjacent factor B gene of 6 kb. A novel restriction fragment length polymorphism (RFLP) has been identified using the endonuclease Sst I and a genomic probe derived from the 5′ region of the C2 gene. Four variants have been detected in a sample of unrelated individuals with haplotypes carrying the C2C allele. Further analysis using C2 and factor B cDNA probes has determined the relationship between this and the other RFLPs previously identified in this region of the genome. Together, the three polymorphisms identified so far make the subdivision of previously indistinguishable haplotypes possible. They therefore constitute a series of markers which increase the resolution of genetic variation in the C2 locus and they may be important in studies of diseases associated with this region of the major histocompatibility complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430921
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Partial characterization of human complement factor H by protein and cDNA sequencing: Homology with other complement and non-complement proteins (1986)
    Springer
    Bioscience reports 6 (1986), S. 65-72 
    Details
    ISSN: 1573-4935
    Keywords: complement ; factor H ; C4b-binding protein, C2, factor B ; β2-glycoprotein ; interleukin-2 receptor ; sequence homology ; cDNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Factor H, a control protein of the human complement system, is closely related in functional activity to two other complement control proteins, C4b-binding protein (C4bp) and complement receptor type 1 (CR1). C4bp is known to have an unusual primary structure consisting of eight homologous units each about 60 amino acids long. Such units also occur in the N-terminal regions of the complement proteins C2 and factor B, and in the non-complement serum glycoprotein β2I. Amino acid sequencing, and sequencing of a factor H cDNA clone, show that factor H also contains internal repeating units, and is homologous to the proteins listed above.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01145180
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Increased hyaluronic acid is associated with dermal delayed-type hypersensitivity (1982)
    Springer
    Inflammation 6 (1982), S. 235-244 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rabbits sensitized subcutaneously with heat-killed bacilli Calmette-Guerin (BCG) and challenged intradermally with heat-killed BCG or purified protein derivative (PPD) demonstrated classical dermal delayed-type hypersensitivity reactions which peaked two days postchallenge. Animals challenged with BCG developed dermal granulomas as measured by induration and gross observation. Challenge with either PPD or BCG resulted in increased levels of dermal hyaluronic acid (HA) by two days postchallenge. Dermal HA returned to normal levels by seven days postchallenge regardless of the challenge antigen. These results indicated that increased HA is associated with dermal delayed-type sensitivity, but increased HA is not associated with dermal granulomatous hypersensitivity. These results are in contrast to previously reported work which indicates that increased HA is associated with both pulmonary delayed hypersensitivity and pulmonary granulomatous hypersensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00916405
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  • 14
    Electronic Resource
    Electronic Resource
    Pulsed field gel electrophoretic analysis of the rat major histocompatibility complex class III region shows extensive inter-species conservation (1994)
    Springer
    Mammalian genome 5 (1994), S. 282-287 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Using pulsed field gel electrophoresis (PFGE), we have examined the rat major histocompatibility complex (MHC) for the presence of a number of new class III region genes recently identified in the human MHC. We find homologous genes to the human G1, G2, G4, G7a, G9, G9a, G10, G13, G15, and G18 genes, but not the G8 gene in the rat genome, and show that these are linked to the rat TNF-α and C4/Slp loci. A long-range restriction map has been constructed on the basis of a PFGE analysis which demonstrates extensive co-linearity in the positions of the homologous sequences in the region between the C4/Slp and TNF loci in the rat MHC when compared with that of the human MHC class III region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389542
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    Paper (German National Licenses)
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