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  • 11
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 465 (1986), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Helgoland marine research 45 (1991), S. 493-511 
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The influence of three bacteria strains (Helgo 21, NCMB 308 and NCMB 13) on the life cycle ofTisbe holothuriae Humes 1957 was investigated under constant experimental conditions (19–20°C and 38‰ S). For each of the first six experiments, females (F1), whose life history was followed, were obtained from a common mother (F0). Experiment no 7 was carried out with adult females (F2) obtained during exp. 4. Females were bred in 50-ml dishes and transferred to a fresh container as soon as they produced a new egg-sac. Offspring (F2: exp. 1–6; F3: exp. 7) from successive egg-layings were counted as soon as they moulted into adults. Larval mortality was estimated by enumeration of the adults issuing from a known number of nauplii that had been fed different bacteria strains. Some difficulties arose in obtaining adults with NCMB 13: it appeared to be necessary to provide this first generation with a small quantity of TetraMin (commercial fish food) in order to initiate reproduction and obtain a second generation. However, in exp. 4, F2 adult females fed NCMB 13 became ovigerous and fertile without needing TetraMin. This result is interpreted as denoting an indispensable period of adaptation to the diet, which probably requires important changes at the enzymatic level. One experiment was carried out with Helgo 21; another one with NCMB 308; two with NCMB 13 (with a unique additional meal of TetraMin to allow reproduction), two with NCMB 13 during larval development, then only tetraMin during adult stage, and one with NCMB 13 alone (with females issued from exp. 4). Data obtained regarding longevity, duration of reproduction period, number of egg-sacs and number of adult descendants show an important variability between bacteria strains. Lower results were almost always obtained with Helgo 21 and NCMB 308. An interesting result lies in the maximum number of egg-sacs: low with Helgo 21 and NCMB 308 (5), but very ample with NCMB 13 (11 in one experiment). In experiment 7, carried out with animals bearing a large coefficient of inbreeding (0.375), the results concerning the maximum number of egg-sacs are good (10) as are the mean number of descendants per female (294: the highest number of the seven experiments). These results indicate that genetic factors involved in the reduction of descendants in ageing laboratory cultures can be suppressed to a certain extent by nutritional factors. The poor results obtained with Helgo 21 and NCMB 308 alone must be considered with caution: after a period of adaptation with an alimentary complement, these strains could perhaps permit an interesting production of copepods.
    Type of Medium: Electronic Resource
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  • 14
    ISSN: 1433-7339
    Keywords: Key words Central venous catheter ; Heparinization ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A phase I study to evaluate heparinization of tunnelled subclavian catheters (TSC) was conducted in 42 patients who each had a TSC for chemotherapy. They were enrolled in the study from August 1994 to December 1995. The inclusion criteria were: age 18–70, no general anticoagulant treatment, TSC used only for chemotherapy, informed consent. Heparinization was performed at the end of each cycle and then at increasing intervals: 11, 13, 15, 17, 19, and 21 days. A 21-day interval was intended to mimic the suppression of heparinization between cycles. Heparinization was performed with a 250 IU/ml heparin solution. Anti-Xa activity was studied before each heparinization. For each interval, at least 5 patients were followed up for two cycles. If no blockages were present progression to the next step was authorized. If one blockage was observed 5 additional patients were required to have their TSCs heparinized after the same interval. Two blockages (block) after the same interval meant that the previous interval was recorded as the longest tolerable. There were no blocks with the 11-day interval (6 patients), 1 block after 13 days (10 patients), 1 block after 15 days (10 patients), and no blocks after 17 days (5 patients), 19 days (6 patients), or 21 days (5 patients). The median anti-Xa activity (curative rate 0.2–0.6) was, respectively 11 days 6.74; 13 days 5.47; 15 days 4.71; 17 days 3.61; 19 days 3.67; 21 days 5.10 (NS). Heparinization between two cycles of chemotherapy is unnecessary. A high level of heparin activity persisted constantly inside the catheter lumen through the 3-week observation period.
    Type of Medium: Electronic Resource
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  • 15
    ISSN: 1435-1463
    Keywords: GDNF ; in situ hybridization ; cell death ; Parkinson's disease ; adult ; newborn infant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for dopaminergic neurons. Since dopaminergic neurons degenerate in Parkinson's disease, this factor is a potential therapeutical tool that may save dopaminergic neurons during the pathological process. Moreover, a reduced GDNF expression may be involved in the pathophysiology of the disease. In this study, we tested whether altered GDNF production may participate in the mechanism of cell death in this disease. GDNF gene expression was analyzed by in situ hybridization using riboprobes corresponding to a sequence of the exon 2 human GDNF gene. Experiments were performed on tissue sections of the mesencephalon and the striatum from 8 patients with Parkinson's disease and 6 control subjects matched for age at death and for post mortem delay. No labelling was observed in either group of patients. This absence of detectable expression could not be attributed to methodological problems as a positive staining was observed using the same probes for sections of astroglioma biopsies from human adults and for sections of a newborn infant brain obtained at post-mortem. These data suggest that GDNF is probably expressed at a very low level in the adult human brain and its involvement in the pathophysiology of Parkinson's disease remains to be demonstrated. GDNF may represent a powerful new therapeutic agent for Parkinson's disease, however.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 14 (1992), S. 203-208 
    ISSN: 1279-8517
    Keywords: Cervical spine ; Anterior approach ; Hypoglossal nerve ; Superior and inferior laryngeal nerves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les suites de la chirurgie du rachis cervical par voie antérieure présternocléidomastoïdienne sont marquées dans un nombre de cas non négligeable par des troubles de la déglutition et de la phonation, et ce, d'autant que l'abord est étendu. 35 dissections sur cadavres ont été réalisées afin de préciser la topographie par rapport aux niveaux vertébraux, le trajet et les variations des éléments nerveux rencontrés lors de cet abord cervical : nerfs laryngés supérieur et récurrent, nerf hypoglosse et la racine supérieure de l'anse cervicale. A partir de cette étude morphologique, les auteurs suggèrent quelques points d' amélioration technique, à chacune des étapes de la dissection, en pratique chirurgicale.
    Notes: Summary The results of the surgical anterior approach to the cervical spine are marked in a number of cases by dysphagia and dysphonia, especially when the approach is extensive or performed at the upper cervical spine. 35 cadaver dissections were performed to define the topography of the nerve structures during operative exposure at various vertebral levels : superior and recurrent laryngeal nerves, hypoglossal nerve and its superior root of the ansa cervicalis. The authors suggest some technical improvements, for each stage of surgical dissection.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 20 (1998), S. 171-176 
    ISSN: 1279-8517
    Keywords: Ligamentum flavum ; Anatomy ; Histology ; Innervation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le lig. jaune (ligamentum flavum), dont peu d'études sont rapportées dans la littérature, a plusieurs particularités mises en évidence dans ce travail. Sur le plan macroscopique, il a une disposition métamérique, il est composé de deux feuillets dont les fibres sont de direction opposée, il entretient des rapports étroits avec certains tendons d'insertion des mm. érecteurs du rachis. Sur le plan microscopique, sa structure est particulière pour un ligament, car y prédominent les fibres élastiques; une innervation lui est propre à chaque niveau vertébral, cette innervation s'appauvrit au fur et à mesure qu'augmente la dégénérescence ligamentaire. Le lig. jaune constitue un système ligamentaire actif, avec un rôle biomécanique essentiel. Le léser n'est sans doute pas sans conséquence, et cela pose des questions techniques concernant les abords chirurgicaux interlamaires.
    Notes: Summary The ligamentum flavum, of which there are only a few studies in the literature, has several features discussed in this work. On the macroscopic level, it has a metameric arrangement: it has two layers, superficial and deep, whose fibers are opposite, and it has close relations with the tendons of attachment of some spinal erector muscles. On the microscopic level, its structure is unique for a ligament, because of a predominance of elastic fibers, because of its intrinsic innervation at each level of the spine, and because this innervation grows poorer with increasing degeneration. The ligamentum flavum constitutes an active ligament, with an essential biomechanical role. Its injury is probably not without consequences, and therefore there are many technical problems about the surgical interlaminar approach.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 20 (1998), S. 171-176 
    ISSN: 1279-8517
    Keywords: Ligamentum flavum ; Anatomy ; Histology ; Innervation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ligamentum flavum, of which there are only a few studies in the literature, has several features discussed in this work. On the macroscopic level, it has a metameric arrangement it has two layers, superficial and deep, whose fibers are oppposite, and it has close relations with the tendons of attachment of some spinal erector muscles. On the microscopic level, its structure is unique for a ligament, because of a predominance of elastic fibers, because of its intrinsic innervation at each level of the spine, and because this innervation grows poorer with increasing degeneration. The ligamentum flavum constitutes an active ligament, with an essential biomechanical role. Its injury is probably not without consequences, and therefore there are many technical problems about the surgical interlaminar approach.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 11 (1989), S. 3-5 
    ISSN: 1279-8517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion L'apparition de l'IRM dans l'arsenal neuro radiologique permet d'obtenir des renseignements topographiques pré-opératoires très précieux pour l'abord chirurgical des tumeurs de l'APC, avec extension antérieure. L'élargissement de la voie transcanalaire sous-temporale, grâce à l'ouverture de la tente permet d'espérer réaliser des exérèses tumorales avec un maximum de chances de conservation de l'audition.
    Type of Medium: Electronic Resource
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  • 20
    ISSN: 1279-8517
    Keywords: Cryosection ; MRI ; Cerebellopontine angle ; Microsurgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'angle ponto-cérébelleux est une région anatomique profondément située à la face antérolatérale du tronc cérébral et dont l'accès est rendu délicat par la présence de pédicules vasculonerveux. L'importance fonctionnelle de ces n. crâniens (trijumeau, facial, vestibulo-cochléaire, glossopharyngien, vague et accessoire) justifie dans certains cas, l'utilisation de voies chirurgicales particulières. En effet, les processus tumoraux, situés entre le paquet acoustico-facial en arrière, et le n. trijumeau en avant, sont d'accès délicat par les voies sous-occipitale et sous-temporale transcanalaire. La tentative de préservation de l'audition dans les situations particulières où le côté contro-latéral à la tumeur n'est plus fonctionnel, justifie l'utilisation d'une voie anatomique sous-temporale transcanalaire élargie par ouverture de la tente du cervelet. L'étude anatomique et chirurgicale expérimentale expose les possibilités de cette voie d'abord.
    Notes: Summary The cerebellopontine angle is an anatomic region situated deeply at the anterolateral aspect of the brainstem, access to which is complicated by the presence of neurovascular bundles. The functional importance of these cranial n. (trigeminal, facial, vestibulo= cochlear, glossopharyngeal, vagus and accessory) calls for the use of special surgical routes of access in certain cases. In particular, tumors situated between the vestibulocochlear-facial bundle behind and the trigeminal n. in front are difficult to reach by the suboccipital and subtemporal transmeatal routes. The endeavor to preserve hearing in particular situations, where the side opposite the tumor is no longer functional, justifies the use of a subtemporal transmeatal route extended by opening the tentorium cerebelli. This anatomic and experimental surgical study deals with the possibilities of this route of approach.
    Type of Medium: Electronic Resource
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