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  • 11
    Electronic Resource
    Electronic Resource
    Crystal structure of the DsbA protein required for disulphide bond formation in vivo (1993)
    [s.l.] : Nature Publishing Group
    Nature 365 (1993), S. 464-468 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The structure of the 189 residue protein DsbA (Fig. 1) was determined at 2 A resolution by a combination of multiple isomorphous replacement (MIR) and multi-wavelength anomalous diffraction (MAD) (Table 1). A notable feature is the presence of a compactly folded helical domain that is inserted ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/365464a0
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  • 12
    Electronic Resource
    Electronic Resource
    Biliary elimination of cyclophosphamide in man (1982)
    Springer
    Cancer chemotherapy and pharmacology 9 (1982), S. 26-29 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 72-year-old male with a lymphoma and obstructive jaundice received 900 mg cyclophosphamide IV as a part of a chemotherapeutic regimen whilst external biliary drainage was in progress. Plasma, urinary, and biliary pharmacokinetics of cyclophosphamide and nitrobenzylpyridine (NBP)-alkylating metabolites were studied. In 32 h 891 ml bile was collected, and this contained unchanged cyclophosphamide and NBP-alkylating material. Despite fluctuations in biliary flow, estimates of the half-life of cyclophosphamide from plasma, urine, and bile were similar. Good correlation existed between plasma and biliary cyclophosphamide concentrations after the initial plasma had been completed. The ratio of bile to plasma concentrations was 0.7 and showed no time dependence, as evidenced by a lack of hysteresis in the correlation curve. Of the administered dose, 3.5% was excreted as unchanged cyclophosphamide in the bile over 32 h. NBP-alkylating activity was found in bile up to 25 h but not after this time, despite the presence of unchanged cyclophosphamide in plasma. NBP-alkylating material was not found in the bile when it could not be detected in plasma, and vice versa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296757
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  • 13
    Electronic Resource
    Electronic Resource
    Gender affects doxorubicin pharmacokinetics in patients with normal liver biochemistry (1995)
    Springer
    Cancer chemotherapy and pharmacology 36 (1995), S. 473-476 
    Details
    ISSN: 1432-0843
    Keywords: Key words Doxorubicin ; Pharmacokinetics ; Gender
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We studied the variability in doxorubicin pharmacokinetics in 27 patients, all of whom had normal liver biochemistry tests. Blood samples were collected after the first cycle of single-agent doxorubicin given as an i.v. bolus and plasma levels were measured by high-performance liquid chromatography (HPLC). The relationship of doxorubicin clearance (dose/AUC) with biochemical tests (AST, bilirubin, alkaline phosphatase, albumin, creatinine) and physical characteristics (age, gender, height, weight, tumour type) was investigated. The 6 men had a significantly higher doxorubicin clearance than did the 21 women (median values, 59 and 27 lh-1 m-2, respectively; P=0.002). Doxorubicin clearance was significantly lower in patients with breast cancer than in those with other tumours (median values, 26 and 53 l h-1 m-2, respectively; P=0.0008). The other biochemical and physical parameters did not correlate with doxorubicin clearance. However, in multivariate analysis, gender was the only factor predicting doxorubicin clearance (r 2=40%). The ratio of the AUCs for doxorubicinol and doxorubicin (R) was higher in the men than in the women (median values, 0.62 and 0.36, respectively; P=0.03). We conclude that gender may be an important determinant of doxorubicin clearance in patients with normal liver biochemistry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685796
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  • 14
    Electronic Resource
    Electronic Resource
    Antenatally detected urinary tract abnormalities: changing incidence and management (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 508-511 
    Details
    ISSN: 1432-1076
    Keywords: Key words Ultrasound ; Urinary tract abnormalities ; Antenatal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To define the incidence of urinary tract abnormalities detected by antenatal ultrasound and assess changes in postnatal management we conducted a retrospective survey using data bases of the nephro-urology unit, obstetric ultrasound and perinatal pathology departments. The birth population (105,542) of the two Nottingham teaching hospitals between January 1984 and December 1993 was divided into two 5-year cohorts, 1984–1988 and 1989–1993. Detailed fetal scanning at 18–20 weeks gestation was introduced in 1989. During this 10-year period, 201 abnormalities of the urinary tract were noted with a 2:1 male to female ratio. The incidence of abnormalities in the first 5 years was 1 in 964 compared to 1 in 364 in the last 5 years. There was a significant increase in the number detected before 20 weeks gestation (12% in 1984–1988 compared to 62% in 1989–1993). Despite the increased incidence of abnormalities detected, the termination rate remained static between the two 5-year cohorts. Only 3 fetuses had intra-uterine intervention and 173 were live-born. Eight infants subsequently died in association with other major congenital abnormalities. The incidence of transient abnormalities (antenatal dilatation with no abnormality noted on postnatal ultrasound) increased from 6% in 1984–1988 to 18% in the 1989–1993 cohort. A more conservative approach to postnatal management is reflected by 71% of infants having operations between 1984 and 1988 compared to 35% in 1989–1993. Conclusion The advent of detailed fetal scanning at 18–20 weeks gestation has significantly increased the detection rate of urinary tract abnormalities with no significant increase in pregnancy termination rates. The need for antenatal intervention is a rare event and most problems can be managed conservatively both pre- and postnatally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050865
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  • 15
    Electronic Resource
    Electronic Resource
    The influence of cimetidine on debrisoquine 4-hydroxylation in extensive metabolizers (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 319-321 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; debrisoquine ; drug interactions ; extensive metabolizers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the effect of cimetidine (800 mg·day−1) administration for three days on debrisoquine 4-hydroxylation in nine healthy extensive metabolizers. The debrisoquine metabolic ratio was significantly increased (p〈0.01), but the new ratios remained in the extensive metabolizer range (〈12.6). These data suggest that pre-treatment with cimetidine in usual therapeutic doses will impair debrisoquine 4-hydroxylation, but not enough to alter the apparent oxidation phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558167
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