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  • 11
    Electronic Resource
    Electronic Resource
    Is there an optimal time for the first cyclosporin dose in renal transplantation? (1993)
    Springer
    Transplant international 6 (1993), S. 223-225 
    Details
    ISSN: 1432-2277
    Keywords: Cyclosporin, renal transplantation, time first dose ; Renal transplantation, cyclosporin, time first dose ; Time first dose, cyclosporin, renal transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is customary for patients undergoing kidney transplantation to receive their first dose of cyclosporin either just before or during the transplant operation. This ensures the early establishment of good levels of immuno-suppression but might depress early graft function and contribute towards the development of acute tubular necrosis. In a controlled clinical trial, we have studied the effects of withholding cyclosporin for 12 h in patients undergoing cadaveric renal transplantation. Consecutive adult recipients of a cadaveric renal transplant were randomised to receive their first dose of cyclosporin (10 mg/kg p. o.) 6 h prior to transplant surgery or 12 h afterwards. All patients received azathioprine (1.5 mg/kg i.v.) and methylprednisolone (0.5 gi.v) in addition during surgery. From the 2nd day onwards both groups were treated with an identical triple immunosuppressive regimen. The 27 patients who received their first dose of cyclosporin post-operatively had significantly better immediate and subsequent function than did the 26 patients who received their cyclosporin at the time of surgery. The delayed dosing was associated with improved graft survival and no increase in the frequency of rejection episodes. This regimen is recommended for all patients receiving triple therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337104
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  • 12
    Electronic Resource
    Electronic Resource
    Comparison of the efficacy of University of Wisconsin solution and Newcastle organ perfusion fluid in the preservation of livers for transplantation (1998)
    Springer
    Transplant international 11 (1998), S. S387 
    Details
    ISSN: 1432-2277
    Keywords: Key words Liver transplantation ; Ischaemia ; Reperfusion ; Organ preservation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract University of Wisconsin solution (UW) is now used widely for the preservation of livers for transplantation. However, the use of commercial solutions has added considerably to the cost. We were able to produce a local version of organ perfusion fluid (NOPF) incorporating all the constituents of UW except for the hydroxyethyl starch and adenosine. We compared graft outcome using NOPF with imported grafts perfused with commercial UW solution. The two recipient groups (15 patients each) were similar with respect to age and sex distribution, urgency of transplantation, regraft status and patient and graft survival. Postoperative duration of ventilation, dialysis requirements, peak bilirubin, peak ALT and lowest unsupported prothrombin time were also similar in both groups. In conclusion, local perfusion fluids based on UW can be produced without detriment to graft outcome with considerable financial savings. At our institution, this represents a reduction of 33 % in the cost of perfusion fluids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050504
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  • 13
    Electronic Resource
    Electronic Resource
    Biliary reconstruction with or without an internal biliary stent in orthotopic liver transplantation: a prospective randomised trial (1998)
    Springer
    Transplant international 11 (1998), S. S245 
    Details
    ISSN: 1432-2277
    Keywords: Key words Biliary complications ; Liver transplant ; Biliary stent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Choledochocholedochostomy (CCD) with a 7 fr/8 fr Cotton Leung internal biliary stent removed at endoscopic retrograde cholangiography (ERC) 3 months following orthotopic liver transplantation (OLT) was the technique used on our unit for biliary reconstruction. From June 1995 to July 1996, we randomised 37 OLT patients with CCDs to receive either an internal stent (group I, nd= 18) or no stent (group II, n = 19). Patients in group I had an ERC at 3 months for stent removal whereas patients in group II had an ERC if indicated. The mean follow up was 19 (13–26) months. Biliary complications occurred in 9 out of 18 patients in group I compared to 1 out of 19 patients in group II (P = 0.007). In group I, ERC was required for complications in 8 patients and early surgery in 2, compared to 1 ERC for abnormal liver function tests in group II. Five of the early complications in group I were stent related. Late biliary stenosis occurred in 1 patient at 9 months. There was one stent-related death. The use of stents contributes to biliary complications and CCD without stenting is safe after OLT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050470
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  • 14
    Electronic Resource
    Electronic Resource
    Immunogold localization of prolamines in developingHaynaldia villosa endosperm (1988)
    Springer
    Protoplasma 144 (1988), S. 25-33 
    Details
    ISSN: 1615-6102
    Keywords: Golgi complex ; Haynaldia villosa ; Immunocytochemistry ; Prolamines ; Protein A-gold ; Protein body
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Haynaldia villosa is a wild grass belonging to the tribe Triticeae, which includes important crops such as wheat, barley, and rye. The alcohol-soluble proteins ofH. villosa have extensive immunological relatedness with wheat prolamines as visualized by Western blot analysis. Amorphous protein inclusions surrounded by a limiting membrane are commonly found in the vacuoles of endosperm and subaleurone layers ofH. villosa seeds. A layer of cells just beneath the aleurone layer is rich in ER. Unlike that in other cell types, the ER in these cells is highly dilated and contains materials at its swollen distal ends. These materials are structurally similar to substances found in the protein bodies. Protein A-gold immunocytochemical localization studies employing antibodies against wheat prolamine confirmed that the inclusions found in the lumen of the ER do not contain prolamines. This observation indicates that the ER does not act as the site of prolamine accumulation inH. villosa. Protein bodies found in the vacuoles and the vesicles associated with the Golgi complexes were specifically labeled. This suggests that Golgi complexes mediate the transport of prolamines into vacuoles ofH. villosa endosperm cells, in a fashion analogous to that of other vacuolar proteins of dicotyledonous plants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01320277
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    Paper (German National Licenses)
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