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  • 11
    Electronic Resource
    Electronic Resource
    cAMP content in rat urine following 10 and 20 days oral administration of a calcium-binding ion exchanger (1979)
    Springer
    Urological research 7 (1979), S. 281-283 
    Details
    ISSN: 1434-0879
    Keywords: cAMP ; Calcium metabolism ; Parathyroid hormone ; Ion-exchanger ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats received a diet containing a Cabinding ion exchanger at a dose of 30 and 90 g/kg diet, respectively. Following 10 days of oral administration there was a dose dependent increase in urinary cAMP excretion. However, after 20 days treatment the measured cAMP content in the urine was no longer different from control values. The results suggest that urinary cAMP excretion in the rat is only of value as an indication of acute changes in PTH-activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256609
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  • 12
    Electronic Resource
    Electronic Resource
    Neurochemical effects of some ergot derivatives: A basis for their antiparkinson actions (1981)
    Springer
    Journal of neural transmission 51 (1981), S. 39-59 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bromocriptine and the two ergoline derivatives, CQ 32-084 and CM 29-712, excert dopamine-like effects in experimental models and have been shown to possess antiparkinsonian activity. Biochemical investigations indicate that they differ in their specificity towards the different dopamine receptor types and, in addition, interact with other neurotransmitter receptors. Bromocriptine appears to be a potent agonist at D2-receptors. Furthermore, it blocks adenylate cyclase coupled serotonin receptors and antagonizes centralα-adrenergic receptors. The two ergoline derivatives are multiple agonists. CQ 32-084 stimulates both D1- and D2-, and CM 29-712 only D2-receptors. In addition, both compounds stimulate adenylate cyclase coupled serotonin receptors and antagonize centralα-adrenergic receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01664004
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  • 13
    Electronic Resource
    Electronic Resource
    Biochemical, behavioural, and endocrine effects of CK 204-933, a novel 8β-ergolene (1987)
    Springer
    Journal of neural transmission 69 (1987), S. 179-199 
    Details
    ISSN: 1435-1463
    Keywords: Ergoline ; dopamine ; noradrenaline ; serotonin ; rat brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary CK 204-933 displaces [3H]dopamine and [3H]spiperonene with high affinity from D-1 and D-2 recognition sites in membranes of calf caudate. Results from functionalin vitro tests suggest that it is a partial agonist at D-1 receptors and an antagonist at D-2 receptors. These opposite effects at dopamine receptor subtypes are also expressedin vivo. For instance, in 6-hydroxydopamine lesioned rats, CK 204-933 induces contralateral rotations which are antagonised by SCH 23390 but not by sulpiride. On the other hand, CK 204-933 induces a long lasting increase of dopamine turnover in rat striatum and antagonises apomorphine-induced gnawing behaviour in rats. CK 204-933 increases prolactin serum levels in rats after subcutaneous administration, whereas after oral administration a moderate decrease of prolactin serum levels was seen. The latter effect is probably due to the formation of active metabolites. CK 204-933 exhibits also a high affinity to [3H]prazosin binding sites and antagonises serotonin-mediated stimulation of adenylate cyclase in rat hippocampus. On the other hand, CK 204-933 has no effect of only very weak effects on noradrenaline and serotonin release from rat cerebral cortex slices, which is consistent with its weak effects on noradrenaline- and serotonin-turnover in rat brain. Based on these properties it is suggested that CK 204-933 could be of therapeutic value in brain diseases associated with disturbances of monoaminergic neurotransmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244340
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  • 14
    Electronic Resource
    Electronic Resource
    Dopamine agonists potentiate antiakinetic effects of competitive NMDA-antagonists in monoamine-depleted mice (1991)
    Springer
    Journal of neural transmission 84 (1991), S. 211-220 
    Details
    ISSN: 1435-1463
    Keywords: Competitive NMDA-antagonists (SDZ EAA-494, CGP 37849) ; dopamine agonists (CI 201-678, SDZ 205-152) ; glutamate ; dopamine ; locomotion ; mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The competitive NMDA-antagonists SDZ EAA-494 and CGP 37849 and the mixed D-1/D-2 dopamine agonists CI 201-678 and SDZ 205-152 reverse akinesia in monoamine-depleted mice in a dose dependent manner. Combination of threshold doses of NMDA-antagonists with dopamine agonists markedly enhances anti-akinetic effects. CI 201-678 which in addition to D-1 and D-2 receptors stimulates α-2 receptors produces a stronger effect than SDZ 205-152 which is devoid of α-2 agonist activity. The results indicate that concomitant blockade of NMDA-receptors and activation of dopamine receptors results in synergistic or at least additive motor stimulatory effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244971
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  • 15
    Electronic Resource
    Electronic Resource
    In vitro effect of the racemic mixture and the (−)enantiomer of N-n-propyl-3-(3-hydroxyphenyl)-piperidine (3-PPP) on postsynaptic dopamine receptors and on a presynaptic dopamine autoreceptor (1983)
    Springer
    Journal of neural transmission 58 (1983), S. 43-53 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The racemic mixture and the (−)enantiomer of the putative dopamine autoreceptor agonist 3-PPP were investigatedin vitro using dopaminesensitive adenylate cyclase in homogenates of rat striatum as a model for a postsynaptic D1-receptor type and inhibition of electrically-evoked tritium overflow from rat striatal slices preincubated with [3H]choline and [3H] dopamine as a model for a postsynaptic D2- and a presynaptic dopamine autoreceptor type, respectively. In contrast, to apomorphine, neither the racemic mixture nor the (−)enantiomer exerted any effect, suggesting agonistic properties in all three receptor models. However, both (±)3-PPP and (−)3-PPP were weak antagonists at postsynaptic D1- and D2-receptors. The results of the present investigation suggest that thein vivo effects of 3-PPP are either the result of metabolic activation or that this drug activates an other dopamine autoreceptor type, pharmacologically different from that one modulating doopamine release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01249123
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  • 16
    Electronic Resource
    Electronic Resource
    [3H]205-501, a Non-catechol dopaminergic agonist, labels selectively and with high affinity dopamine D2 receptors (1985)
    Springer
    Journal of neural transmission 62 (1985), S. 231-248 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary [3H]205–501, a noncatechol dopaminergic agonist, is presented as a ligand with high affinity (KD ∼ 1 nM) and high selectivity for dopamine receptors. pKi values of dopaminergic agonists derived from competition isotherms in the [3H]205–501 binding assay correlate very well with their potency in the acetylcholine release assay, which is controlled by dopamine D2 receptors. There is however no correlation with their potency stimulating adenylate cyclase, a process controlled by dopamine D1 receptors. Thus [3H]205–501 is the first agonist ligand selective for dopamine D2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01252239
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  • 17
    Electronic Resource
    Electronic Resource
    SDZ PSD 958, a novel D1 receptor antagonist with potential limbic selectivity (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 261-276 
    Details
    ISSN: 1435-1463
    Keywords: SDZ PSD 958 ; D1 receptor antagonist ; catalepsy ; rearing ; stereotypy ; locomotion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary SDZ PSD 958, a novel benzo[g]quinoxaline derivative exhibits the properties of a potent orally active selective D1 receptor antagonist. It has high affinity for D1-like receptors (D1, D5; pKi=9.7–9.8) labelled by [3H]SCH23390 and is at least 400 fold less active at D2-like receptors (i.e. D2, D4) labelled by [3H]spiperone. Effects in functional tests are consistent with d1 receptor antagonist properties. SDZ PSD 958 inhibited apomorphine-induced rearing in mice and prevented prolongation of novelty-induced locomotion in rats elicited by the selective D1 receptor agonist CY 208-243. By contrast, SDZ PSD 958 did not induce catalepsy and only weakly inhibited apomorphine-induced stereotyped gnawing in rats. This suggests that SDZ PSD 958 preferentially inhibits responses mediated by dopamine systems innervating the limbic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271238
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  • 18
    Electronic Resource
    Electronic Resource
    SDZ GLC 756, a novel octahydrobenzo[g]quinoline derivative exerts opposing effects on dopamine D1 and D2 receptors (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 17-30 
    Details
    ISSN: 1435-1463
    Keywords: SDZ GLC 756 ; octahydrobenzo[g]quinoline ; dopamine D1 receptor ; dopamine D2 receptor ; prolactin ; circling (rats) rearing (mice)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary SDZ GLC-756, a novel octahydrobenzo[g]quinoline derivative, is equipotent in displacing [3H]SCH23390 from dopamine D1 receptors and [3H]205–501 from dopamine D2 receptor binding sites. It blocks dopamine sensitive adenylate cyclase with the same potency as SCH23390, indicating antagonist properties at dopamine D1 receptors. On the other hand, SDZ GLC 756 inhibits electrically evoked acetylcholine release from rat striatal slices with the same potency as the selective dopamine D2 receptor agonist bromocriptine. This effect is blocked by spiperone suggesting that it is mediated by dopamine D2 receptor activation. The opposing action of SDZ GLC 756 on dopamine D1 and D2 receptors is also evident in vivo. SDZ GLC 756, like SCH23390, blocks apomorphine-induced rearing in mice. On the other hand, it inhibits prolactin secretion and produces circling in unilateral 6-OHDA-lesioned rats, which is compatible with stimulant properties at dopamine D2 receptors. This drug might be a new tool to study linkage between dopamine D1 and D2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292613
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  • 19
    Electronic Resource
    Electronic Resource
    Oxydative Demethylierung durch Leberhomogenat von Ratten nach Vitamin E-Mangel und nach Tocopherolgaben (1971)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 54 (1971), S. 2568-2572 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Zusammenfassung. Das sauerstoffabhängige demethylierende Enzymsystem aus Leberhomogenat oder Lebermikrosomenpräparaten wird durch α-Tocopherol nicht beeinflusst. Eine deutliche, aber langsamer verlaufende Enzyminduktion nach Angewöhnung mit dem Substrat (N-Methyl-glutethimid) ist indessen auch in durch Vitamin E-Mangel geschädigten Zellen nachweisbar.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19710540821
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