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  • 11
    Electronic Resource
    Electronic Resource
    Localization of the major house dust mite allergen Der p I in the body of Dermatophagoides pteronyssinus by ImmuStain® (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1992.tb00181.x
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  • 12
    Electronic Resource
    Electronic Resource
    House dust mite sensitivity: interaction of genetics and allergen dosage (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pairwise analysis of siblings from 21 families showed that house dust mite (HDM) sensitive children were exposed to higher concentrations of Der p I allergen in their mattress (P= 0.005) and bedding (P= 0.04), but not bedroom floor (P= 0.33), than their atopic sibling who was not sensitive to HDM antigens. There was no difference in the exposure to HDM numbers/100 mg of dust in the mattress (P= 0.61) or bedroom floors (P= 0.09). In contrast, pairwise analysis of siblings from 15 families showed that HDM sensitive children were not exposed to significantly different concentrations of Der p I in the mattress (P= 0.96), bedding (P= 0.11) or bedroom floor (P= 0.70) nor HDM numbers/100 mg of dust in the mattress (P= 0.12) and bedroom floor (P= 0.98) than their non-atopic siblings. These findings were identical when absolute allergen load was compared in these pairs. Genetic linkage studies in these families suggest the tendency to atopic IgE responses is conferred by a putative atopy locus on chromosome 11q. These results together suggest that differences in allergen levels in beds, among siblings with a comparable genetic tendency to atopy, play a significant role in determining the development of HDM allergy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1992.tb03074.x
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  • 13
    Electronic Resource
    Electronic Resource
    The use ofdomestic steam cleaning for the control of house dust mites (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Control of dust mites using extremes of temperature is un alternative to the use of acaricides. In ihe past we have attempted control by freezing with liquiid nitrogen. The present paper deals with the opposite exlrcnic, the use of steam.Objective To assess the feasibility inid effectiveness of a domestic steam cleaner for the control of dust mites. its effect on mite populations and concentrations of the allergen Der p I.Methods A domestic steam cleaner was used to treat earpet squares that had been seeded in the laboratory with known numbers of dust mites (Dermatophagoides pterpmussomis). The number of live mites was monitored for a period of 4 months in eight treated earpet squares and eight controls. Dust samples were taken from 12 standardized areas of carpet in a tenement flat in Glasgow, UK., before and after steam cleaning treatmet. and the concentration of allergen Der p 1 was compared with 12 adjacent. control areas.Results No live mites were found at any time in the treated carpet squares, whereas in the control squares geometric mean mite population density rose frotn 11 after 3 days to 39 after 1 month, 66 after 2.122 after 3 and 185 after 4 months. There was a mean reduetion of 8.7% in Der p I concentration (3.3-0.44 μg/g) compared with a reduction of 4.7% (2.22-2.l16μg/g) in control areas, a difference that was statistically significant at the 5% level.Conclusion These data indicate that steam cleaning has considerable potential as an highly effective and efficient method of killing dust mites and reducing concentrations of Der p 1 in domestic premises.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1995.tb03252.x
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  • 14
    Electronic Resource
    Electronic Resource
    Immediate hypersensitivity, IgE and asthma (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 14 (1984), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-one asthmatic and twenty-two non-asthmatic children and nine asthmatic adults from two different rural areas of Tanzania, and eight asthmatic children from Dar-es-Salaam were surveyed by questionnaires, skin testing and the measurement of serum IgE. Asthma was significantly commoner in female rural children (four males, fifteen females). The rural asthmatic children apparently had less skin reactivity (in seven of nine tests) and lower specific (in two of four tests) and total serum IgE than age-, sex- and village-matched controls. This pattern of asthma in rural children in the tropics represents a different type of asthma from that found in temperate zones. In contrast, the adult rural asthmatics and the urban children seemed to have the pattern of increased skin reactivity and serum IgE found in asthmatic patients from temperate climates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1984.tb02222.x
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  • 15
    Electronic Resource
    Electronic Resource
    Phadiatop—a novel IgE antibody screening test (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 17 (1987), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The Phadiatop® test, which is based on a multi-allergen allergosorbent, proved to be a test that is simple to perform in the laboratory and produces reliable results. When compared with the more conventional RAST atopy screening test for grass, mite and IgE antibodies it produced similar results, except in those rare instances of patients who were RAST-positive only for moulds where the Phadiatop test was decidedly superior. The Phadiatop test disc contains only inhalant allergens and so it could not be used for screening infants and very young children whose IgE response, if any, is probably limited to foods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1987.tb02034.x
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  • 16
    Electronic Resource
    Electronic Resource
    Feather mites are potentially an important source of allergens for pigeon and budgerigar keepers (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Previous studies on allergy to feathers have not adddressed whether orgatiisms living on feathers (mites. lice, moulds) are a source of allergens.Objective To investigate whether feather mites produced allergens of clinical relevance to bird keepers.Methods We examined serum IgE responses of 96 pigeon breeders to an extract of feather mites from pigeons (predominantly Diplaegidia columbae). using Western blotting, specific IgE assay using AlaSTAT EIA and RAST inhibition.Results Feather mites are a major source of soluble proteins derived from feathers, accounting for up to 10% of the total weight of the feather. Forty-three sera had a negative score (0) for anti-feather mite IgE. 27 were weakly positive (1–2) and 26 had strongly positive scores (3–4). Fewer pigeon breeders with scores ± 3 were asymptomatic than those with negative scores (12 versus 40%). more had late onset symptoms (with or without early onset symptoms; 77% versus 44%) and had IgE antibody against house dust mite (89% versus 23%). Western blotting of eight sera against the extract of Diplaegidia columbae revealed 20 IgE-binding components ranging from 22 to 200 kDa. A high diversity of components was recognized by each serum: arithmetic mean 7 (range 2 14). RAST inhibition indicated feather mites had species-specific epitopes as well as ones that cross-reacted with Dermatophagoides pteronyssinus.Conclusion Strongly-positive AlaSTAT scores to pigeon leather mite were associated with allergic symptoms of late onset in pigeon breeders. We conclude that feather mites are a major source of clinically-relevant allergens for pigeon breeders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1997.tb00673.x
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  • 17
    Electronic Resource
    Electronic Resource
    Allergy and parasites: the measurement of total and specific IgE levels in urban and rural communities in Rhodesia (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 6 (1976), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eighty adult asthmatics living in an African city had a significantly higher serum IgE level (799 u/ml) than the control group (350 u/ml). A high proportion (78·7%) of the asthmatics had demonstrable circulating mite-specific IgE antibodies. The rural population of a filariasis endemic region was investigated and although no allergic subjects were identified, the group had a significantly higher IgE level (1613 u/ml) than the asthmatics and also showed a relatively high incidence of grass pollen-specific IgE antibodies (35%). The discrepancy between clinical history and laboratory results supports the mast cell saturation hypothesis and suggests: (a) an explanation for the susceptibility to allergy of African and Asian immigrants to Great Britain, and (b) a practical approach for preventing allergic reactions in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1976.tb01890.x
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  • 18
    Electronic Resource
    Electronic Resource
    Prevalence of atopy is unrelated to presence of inflammatory bowel disease (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 18 (1988), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The prevalence of atopy (assessed by prick testing and serum IgE measurement), and of symptoms associated with atopy, has been defined in 122 patients with inflammatory bowel disease (IBD) and 103 age-matched controls. History analysis for atopic symptoms, and serum IgE levels, showed no differences between controls and IBD patients, or IBD subgroups (Crohn's disease, ulcerative colitis, ulcerative proctitis). Both in controls and in IBD patients, the prevalence of positive skin tests was higher in young people (aged 〉 30) than in others; taking account of age distribution within the groups, there were no differences between controls and IBD patients, or subgroups, in the prevalence of positive skin tests. Our findings do not support the hypothesis that reaginic hypersensitivity plays a significant role in the pathogenesis of IBD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1988.tb02850.x
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  • 19
    Electronic Resource
    Electronic Resource
    The development of allergy in high-risk children (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background It is uncertain as to what extent the development of allergic disease in childhood is predictable during early infancy. A number of environmental factors have been suspected of increasing the risk of acquiring allergy, but the evidence is conflicting.Objective To observe the development of atopy and allergic disease in a cohort of high-risk children so as to determine the importance of certain environmental factors and to study the relationship between early and later manifestations.Methods A cohort of infants, all at high risk of allergy, was followed up from birth to the age of 7 years. In half, selected at random, cow's milk protein was avoided for 4 months. Skin-prick tests were performed and serum IgE measured in infancy and at 7 years, when an AlaTOP test was also performed.Results Skin sensitivity to egg in the first year of life was strongly associated with eczema, asthma, mite sensitivity and serum IgE at the age of 7 years, when mother's atopic history was associated with AlaTOP status, father's atopic history with skin sensitivity, and male sex with both. Maternal smoking during pregnancy was associated positively with IgE at 3 months and negatively with skin sensitivity at 7 years. The development of allergy was unrelated to infant feeding method or number of older siblings.Conclusion Allergic disease in childhood is to a large degree determined before birth or during infancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1997.tb01168.x
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  • 20
    Electronic Resource
    Electronic Resource
    RAST atopy screen (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 8 (1978), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A single in vitro screening test for atopic allergy is described. It uses the radioallergosorbent test (RAST) principle, and has been applied to screening sera from U.K. patients with possible atopic symptoms.When compared with the Phadebas RAST, the test sensitivity was 97% and the specificity 100%, and these results suggest that it is useful in any preliminary allergy investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1978.tb03219.x
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