ISSN:
0570-0833
Keywords:
Hexamethylphosphoramide
;
HMPA (hexamethyl phosphoramide)
;
Solvents
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Growing interest is being shown in the role of the solvent (particularly polar solvents) in chemical reactions[1-4]. The most remarkable polar aprotic solvent appears to us to be the hexamethylated triamide of orthophosphoric acid, OP(N(CH3)2)3, which is known as hexamethylphosphoramide or tris(dimethylamino)phosphine oxide. Hexamethylphosphoramide[5-7] has recently been studied with respect to its solvent properties for gases[5], for many organic and inorganic salts[7], and for polymers[5], as well as its use as a polymerization co-catalyst. However, these aspects are not considered in the present paper, which deals with the physical and chemical properties of hexamethylphosphoramide, and in particular with its use as a reaction medium. Our own work on hexamethylphosphoramide began in 1961, and until then very little work had been done on this compound. Even in a paper published by Parker[1b] in 1965, very little reference is made to hexamethylphosphoramide.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.196710461
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