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  • 11
    Electronic Resource
    Electronic Resource
    Dynamics of chronic myeloid leukaemia (2005)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 435 (2005), S. 1267-1270 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The clinical success of the ABL tyrosine kinase inhibitor imatinib in chronic myeloid leukaemia (CML) serves as a model for molecularly targeted therapy of cancer, but at least two critical questions remain. Can imatinib eradicate leukaemic stem cells? What are the dynamics of relapse due to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature03669
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Cancer Mixing cocktails (2007)
    [s.l.] : Nature Publishing Group
    Nature 449 (2007), S. 993-996 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Certain cancers are caused by oncogenic primary or 'driver' mutations in specific kinases — enzymes that regulate the activity of other proteins. Consequently, kinase inhibitors have been used in the clinic as effective single-agent drugs to shrink tumours. Kinase 'addiction' persists in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/449993a
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Mechanistic Concepts in Androgen-dependence of Prostate Cancer (1998)
    Springer
    Cancer and metastasis reviews 17 (1998), S. 421-427 
    Details
    ISSN: 1573-7233
    Keywords: hormone-refractory ; tyrosine kinase ; Her-2/neu ; androgen receptor ; co-activator ; co-repressor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Androgen blockade is the mainstay of therapy in the clinical management of advanced prostate cancer. Recent progress on two fronts – the development of newer xenograft and transgenic models and a greater understanding of nuclear receptor signaling – has provided new insight into mechanisms of androgen-dependence in prostate cancer. This review centers on the concept that perturbations in androgen receptor signaling are likely to occur early in prostate cancer and play a critical role in progression to end stage hormone-refractory disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006141806801
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    Paper (German National Licenses)
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