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  • 11
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Electroanalytical Chemistry 142 (1982), S. 85-94 
    ISSN: 0022-0728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Electroanalytical Chemistry 194 (1985), S. 317-325 
    ISSN: 0022-0728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Electroanalytical Chemistry 194 (1985), S. 305-315 
    ISSN: 0022-0728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Bioorganic & Medicinal Chemistry Letters 4 (1994), S. 2825-2830 
    ISSN: 0960-894X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 35 (1992), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Monoclonal antibodies to CD3 can induce proliferation of resting T cells. In vitro this effect is dependent on the presence of monocytes. They serve as accessory cells providing a co-stimulatory signal after cross-linking of the antibody-coated TcR/CD3 complex by the Fc receptor on the monocytes. We have studied whether endothelial cells can replace monocytes with regard to (his function. Highly purified T-cell preparations were cultured in the presence of anti-CD3 antibody, purified monocytes, and human umbilical vein endothelial cells. Anti-CD3 and endothelial cells alone were unable in support T -cell proliferation, due to lack of FcR expression. Addition, however, of as few as 10110 FcR+ monocytes (0.8% of the number of T cells present) to a co-culture of T cells and endothelial cells (EC) in the presence of soluble anti-CD3 resulted in a strong proliferation of T cells. When anti-CD3 was presented in an immobilized form (coated to the culture well or to Sepharose beads), or when phytohaemagglutinin was added to the culture as a cross-linking agent, EC could support T-cell proliferation in the absence of any monocytes. We conclude that EC by themselves cannot support the proliferation of pure T cells induced by soluble anti-CD3, but are potent generators of the co-stimulatory signal(s). They provide a suitable starling material to further define this co-stimulatory activity.
    Type of Medium: Electronic Resource
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  • 16
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have previously reported a polymorphism in the mitogenic effect of murine (m) IgG1 anti-CD3 monoclonal antibodies. This polymorphism was genetically determined and could be attributed to polymorphism of the Fc receptor (FcR) for mIgG1 present on human monocytes. We have now extended these studies by quantitating FcR expression on monocytes and cell lines by a recently developed EA rosette assay, using the erythrocyte-associated pseudoperoxidase activity. The data show that the polymorphism of the monocyte FcR for mIgG1 is based on a quantitative rather than an absolute difference. Furthermore, this FcR is specific for mIgG1 and does not bind mIgG2a or mIgG2b nor, surprisingly, human IgG. The expression of this FcR on cell lines correlates with their accessory function in IgG1 anti-CD3-induced T cell proliferation. mIgG2a can inhibit the rosetting of monocytes with erythrocytes sensitized with human IgG. The FcR detected by this rosette technique can interact with all four human IgG subclasses but not with mIgG1 or mIgG2b. The expression of this type of FcR on human cell lines correlates well with their ability to support mIgG2a anti-CD3-induced mitogenesis. These direct measurements of FcR expression support the concept that human monocytes have two independent FcR with affinity for mouse IgG: one receptor specigic for mIgG2a (which also binds human IgG), and a second specific for mIgG1.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    TrAC Trends in Analytical Chemistry 7 (1988), S. 370-374 
    ISSN: 0165-9936
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 85 (1996), S. 586-605 
    ISSN: 1437-3262
    Keywords: Carbonate ramp ; Sequence stratigraphy ; Cyclostratigraphy ; Pyrenees ; Aptian ; Albian
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract High-frequency cycles in Upper Aptian carbonates have been studied on the carbonate ramp of Organyà (southeastern Pyrenees). The depositional area comprises a shallow marine to deeper marine transect. A detailed facies model is developed subdividing the transect into an inner ramp area (above fairweather wave base), a mid-ramp area (between fairweather wave base and storm wave base) and an outer ramp area (below storm wave base). Based on microfacies analysis a cyclostratigraphic and sequence stratigraphic interpretation is established. Variations of the sedimentary patterns within different sections of the homoclinal ramp are due mainly to sea level changes. Sea level changes of third and fourth order are reflected by the shifting of the shallow subtidal facies belts up and down the ramp. The study of fifth-order sea level changes is based on statistical methods (quantitative facies analysis and principal component analysis). The ratio of the fourth- and fifth-order cycles is very similar to the well-known ratio of the eccentricity (100 ka) and the precession (18.6/22.5 ka). The absolute age values derived from the cyclostratigraphy fit into the biostratigraphic framework. Thus, a global eustatic control is assumed to be responsible for the cycles of higher frequency. The lower frequency third-order sequences, however, were considerably influenced by local tectonic processes.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 85 (1996), S. 723-754 
    ISSN: 1437-3262
    Keywords: Biostratigraphy ; Lower Tertiary ; Indian shelf ; Upper Cretaceous ; Foraminifers ; Lithostratigraphy ; Passive continental margin ; Tethys Himalaya ; Tibet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The 1500-m-thick marine strata of the Tethys Himalaya of the Zhepure Mountain (Tingri, Tibet) comprise the Upper Albian to Eocene and represent the sedimentary development of the passive northern continental margin of the Indian plate. Investigations of foraminifera have led to a detailed biozonation which is compared with the west Tethyan record. Five stratigraphic units can be distinguished: The Gamba group (Upper Albian - Lower Santonian) represents the development from a basin and slope to an outer-shelf environment. In the following Zhepure Shanbei formation (Lower Santonian - Middle Maastrichtian), outer-shelf deposits continue. Pebbles in the top layers point to beginning redeposition on a continental slope. Intensified redeposition continues within the Zhepure Shanpo formation (Middle Maastrichtian - Lower Paleocene). The series is capped by sandstones of the Jidula formation (Danian) deposited from a seaward prograding delta plain. The overall succession of these units represents a sea-level high at the Cenomanian/Turonian boundary followed, from the Turonian to Danian, by an overall shallowing-upward megasequence. This is followed by a final transgression — regression cycle during the Paleocene and Eocene, documented in the Zhepure Shan formation (?Upper Danian - Lutetian) and by Upper Eocene continental deposits. The section represents the narrowing and closure of the Tethys as a result of the convergence between northward-drifting India and Eurasia. The plate collision started in the Lower Maastrichtian and caused rapid changes in sedimentation patterns affected by tectonic subsidence and uplift. Stronger subsidence and deposition took place from the Middle Maastrichtian to the Lower Paleocene. The final closure of remnant Tethys in the Tingri area took place in the Lutetian.
    Type of Medium: Electronic Resource
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  • 20
    ISSN: 1437-3262
    Keywords: Key words Calcareous dinoflagellate cysts ; Palaeoceanography ; Late Quaternary ; Glacial Terminations ; South Atlantic Ocean
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Despite the increasing interest in the South Atlantic Ocean as a key area of the heat exchange between the southern and the northern hemisphere, information about its palaeoceanographic conditions during transitions from glacial to interglacial stages, the so-called Terminations, are not well understood. Herein we attempt to increase this information by studying the calcareous dinoflagellate cysts and the shells of Thoracosphaera heimii (calcareous cysts) of five Late Quaternary South Atlantic Ocean cores. Extremely high accumulation rates of calcareous cysts at the Terminations might be due to a combined effect of increased cyst production and better preservation as result of calm, oligotrophic conditions in the upper water layers. Low relative abundance of Sphaerodinella albatrosiana compared with Sphaerodinella tuberosa in the Cape Basin may be the result of the relatively colder environmental conditions in this region compared with the equatorial Atlantic Ocean with high relative abundance of S. albatrosiana. Furthermore, the predominance of S. tuberosa during glacials and interglacials at the observed site of the western Atlantic Ocean reflects decreased salinity in the upper water layer.
    Type of Medium: Electronic Resource
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