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  • 11
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 663 (1992), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 81 (1997), S. 4116-4118 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: (Fe,Ti)–N thin films with titanium concentrations 3–35 at. % were prepared at room temperature by facing targets sputtering. X-ray diffraction and transmission electron microscopic studies were employed to characterize various phases observed prior to and during in situ annealing of (Fe,Ti)–N films. The films with 3–10 at. % Ti contained an α-(Fe,Ti) phase and an α′-martensite phase and the films with 20–35 at. % Ti comprised α-Fe(N), α′-martensite, and TiN phases in the as-deposited samples. The annealing temperature (TA) was increased from RT to 800 °C in increments of 50 °C. Annealing of the samples with 8 at. % Ti showed no structural changes between RT and 300 °C, but when the sample was heated to 400 °C, α′′ and TiN phases appeared in the microstructure. The samples with 25 at. % Ti also showed no structural changes when heated to 400 °C. When TA=500 °C, α′′ phase formed in the microstructure. The phases formed at 400 or 500 °C in the two samples were stable when the samples were heated up to 800 °C and followed by cooling down to RT. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Asthma is a common chronic disease and information on its management practices at the community level is helpful in identifying problems and improving asthma care.Objective To assess the severity status and management of the asthma symptom of wheeze of children at the community level in Hong Kong (HK) and Guangzhou (GZ).Methods Cross-sectional study of children aged 10 years using the International Study of Asthma and Allergic disease in Childhood (ISAAC Phase II protocol). Asthma management and lung function were assessed in 178 (98 from HK and 80 from GZ) randomly selected children with wheeze over the past 12 months.Results Eighty-three percent, 11%, 6% and 0% of children suffered from intermittent, mild persistent, moderate persistent and severe persistent asthma, respectively, according to the frequency of their symptoms. Addition of spirometric parameter only changed the asthma severity classification in 2.8% of children. Medications were used by 30.6% and 71.3% of children for wheeze in HK and GZ, respectively. In HK, inhaled β2-agonist (73.3% among the drug users) was the commonest medication used followed by inhaled corticosteroid (ICS) (23.3%). In GZ, inhaled β2-agonist was used by 75.4% of children, but use of ICS (26.3%), oral β2-agonist (26.3%), oral theophylline (45.6%), oral ketotifen (36.8%) and oral steroid (35.1%) were also common. ICS was only used by 11.4% of children with persistent asthma. Ten percent and 18.7% of children in HK and GZ, respectively, had emergency department visits, while 16.3% and 11.6% of children in HK and GZ, respectively, had missed school secondary to asthma over the past 1 year.Conclusions Most children in the community had intermittent asthma and addition of lung function to symptoms did not significantly affect classification of asthma severity. Significant morbidity was seen even in this group of children with mostly intermittent and mild persistent asthma.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytical Biochemistry 142 (1984), S. 369-372 
    ISSN: 0003-2697
    Keywords: amino acid ; continous assay ; pyrophosphate ; spectrophotometric ; synthetase ; tRNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background β-Catenin, a participant in the Wnt pathway, has been shown to play an important role in the morphogenesis of hair follicles and the formation of hair follicle-related tumours, including pilomatricomas. It has been observed that at least 75% of human pilomatricomas possess activating mutations in β-catenin. These findings suggested that β-catenin plays an important role in the tumorigenesis of pilomatricomas. However, the pattern of β-catenin expression in pilomatricoma tissues is still unclear. Objectives To examine the expression of β-catenin in human pilomatricomas by immunohistochemical staining. Methods Twenty-six formalin-fixed and paraffin-embedded samples of pilomatricoma tissue were studied. Results Most transitional cells of pilomatricoma expressed β-catenin strongly, but the basophilic cells and shadow cells did not. β-Catenin showed a prominent membranous immunoreactivity and a small amount of condensed cytoplasmic staining, but there was definitely no evidence of nuclear positivity. Conclusions These findings imply that β-catenin is primarily involved in cell–cell adhesion rather than cellular proliferation during pilomatricoma pathogenesis, and suggest that if β-catenin is involved in pilomatricoma tumorigenesis and tumour growth, it plays an indirect role.
    Type of Medium: Electronic Resource
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  • 16
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Amyloid has recently been shown to accumulate intracellularly in the brains of patients with Alzheimer's disease (AD), yet amyloid plaques are generally thought to arise from gradual extracellular amyloid deposition. We have investigated the possibility of a link between these two apparently conflicting observations.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and results:Immunohistochemistry and digital image analysis was used to examine the detailed localization of β-amyloid42 (Aβ42), a major component of amyloid plaques, in the entorhinal cortex and hippocampus of AD brains. Aβ42 first selectively accumulates in the perikaryon of pyramidal cells as discrete, granules that appear to be cathepsin D-positive, suggesting that they may represent lysosomes or lysosome-derived structures. AD brain regions abundantly populated with pyramidal neurones exhibiting excessive Aβ42 accumulations also contained evidence of neuronal lysis. Lysis of these Aβ42-burdened neurones apparently resulted in a local, radial dispersion of their cytoplasmic contents, including Aβ42 and lysosomal enzymes, into the surrounding extracellular space. A nuclear remnant was found at the dense core of many amyloid plaques, strengthening the idea that each amyloid plaque represents the end product of a single neuronal cell lysis. The inverse relationship between the amyloid plaque density and pyramidal cell density in the AD brain regions also supports this possibility, as does the close correlation between plaque size and the size of local pyramidal cells.〈section xml:id="abs1-3"〉〈title type="main"〉Conclusions:Our findings suggest that excessive intracellular accumulation of Aβ42-positive material in pyramidal cells can result in cell lysis, and that cell lysis is an important source of amyloid plaques and neuronal loss in AD brains.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 985 (1989), S. 199-210 
    ISSN: 0005-2736
    Keywords: Acidic lipid ; Interdigitation ; Lipid bilayer ; Phase transition ; Polymyxin B ; Polymyxin B nonapeptide ; Spin label
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 985 (1989), S. 182-198 
    ISSN: 0005-2736
    Keywords: Interdigitation ; Lipid bilayer ; Phase transition ; Polymixin B nonapeptide ; Polymyxin B ; Spin label
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 289 (1991), S. 274-280 
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Biochemistry 16 (1984), S. 1379-1385 
    ISSN: 0020-711X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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