ISSN:
1432-1041
Keywords:
molsidomine
;
myocardial infarction
;
haemodynamic effects
;
pump failure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Haemodynamic monitoring, using a Swan-Ganz balloon catheter, was done in 14 patients with pump failure associated with acute myocardial infarction, before and for 8 h after single 6 mg oral dose of molsidomine. The following changes effects were found: HR fell by 1.6 to 4.7% (significant at 4th hour; p〈0.05); SBP was 8.4% lower after 1 h (p〈0.05); PCP was decreased by approximately 30%, a significant effect that lasted for 8 hours (p〈0.002). CI did not change significantly, although individual analysis showed it to have increased in 6 out of 12 cases. Stroke volume index was increased by about 6% (significant after 1 h, p〈0.025). The left ventricular stroke work index also increased from 9.8 to 24.5% (significant after 1 and 4 h, p〈0.01 and 0.025). These findings show the beneficial haemodynamic effects of molsidomine in pump failure complicating acute myocardial infarction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00549588
Permalink
