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Notizen: Aims 〈list xml:id="l1-14" style="custom"〉1 To identify the outcome status of women with borderline and mild dyskaryosis smears.2To determine whether the presence or absence of koilocytosis influences the outcome status.3To identify the proportion of women with borderline smears showing koilocytosis.Materials and methods  Borderline and mild dyskaryosis cervical smears diagnosed during January to March 1997 were identified from the laboratory database. Each slide was reviewed by two researchers independently, who then agreed a final consensus diagnosis. All slides were classified according to the presence or absence of koilocytosis. Slides were excluded from the study if the review diagnosis was negative, inadequate or high-grade dyskaryosis. The outcome status was classified according to the worst lesion identified histologically and/or cytologically during the 5-year follow-up period.Results  1974 women were identified with borderline or mild dyskaryosis cervical smears of which 1597 were included in the study. 〈link href="#t1-14"/〉〈link href="#t1-14"〉Table 1 shows the outcome status of these women.〈tabular xml:id="t1-14"〉1. 〈title type="main"〉 The outcome status of these women 〈table frame="topbot"〉〈tgroup cols="4" align="left"〉〈colspec colnum="1" colname="col1"/〉〈colspec colnum="2" colname="col2"/〉〈colspec colnum="3" colname="col3"/〉〈colspec colnum="4" colname="col4"/〉〈thead valign="bottom"〉〈row rowsep="0"〉〈entry valign="bottom" morerows="1"〉Cytology〈entry rowsep="1" namest="col2" nameend="col4"〉Outcome status〈row rowsep="1"〉Negative (%)Low-grade (%)High-grade (%)〈tbody valign="top"〉Borderline681913Mild dyskaryosis462628 〈link href="#t2-14"/〉 〈link href="#t2-14"〉Table 2 shows the outcome of women with borderline and mild dyskaryosis smears with or without koilocytosis.〈tabular xml:id="t2-14"〉2〈title type="main"〉 The outcome of women with borderline and mild dyskaryosis smears with or without koilocytosis 〈table frame="topbot"〉〈tgroup cols="4" align="left"〉〈colspec colnum="1" colname="col1"/〉〈colspec colnum="2" colname="col2"/〉〈colspec colnum="3" colname="col3"/〉〈colspec colnum="4" colname="col4"/〉〈thead valign="bottom"〉〈row rowsep="0"〉〈entry valign="bottom" morerows="1"〉Koilocytosis〈entry rowsep="1" namest="col2" nameend="col4"〉Outcome status〈row rowsep="1"〉Negative (%)Low-grade (%)High-grade (%)〈tbody valign="top"〉Present582220Absent612118 〈link href="#t3-14"/〉 〈link href="#t3-14"〉Table 3 shows the proportion of borderline and mild dyskaryosis cervical smears with or without koilocytosis.〈tabular xml:id="t3-14"〉3〈title type="main"〉 The proportion of borderline and mild dyskaryosis cervical smears with or without koilocytosis 〈table frame="topbot"〉〈tgroup cols="3" align="left"〉〈colspec colnum="1" colname="col1"/〉〈colspec colnum="2" colname="col2"/〉〈colspec colnum="3" colname="col3"/〉〈thead valign="bottom"〉〈row rowsep="1"〉CytologyKoilocytosis present (%)Koilocytosis absent (%)〈tbody valign="top"〉Borderline2476Mild dyskaryosis3466Conclusions 〈list xml:id="l2-14" style="custom"〉1Sixty-eight per cent of women with a borderline cervical smear had a normal outcome.2Thirteen per cent of women with a borderline cervical smear developed a high-grade lesion.3The presence or absence of koilocytosis in borderline and mild dyskaryosis cervical smears does not appear to affect the outcome status of these women.4Twenty-four per cent of smears showing borderline nuclear changes were found to have koilocytosis.

Notizen: This study investigated the 5-year follow-up status of women with cervical smears showing borderline nuclear changes (BNC) or mild dyskaryosis and the effect of koilocytosis on the outcome. Thirteen per cent of women with cervical smears showing BNC had high-grade cervical intraepithelial neoplasia (CIN). In contrast, 28% of women with cervical smears showing mild dyskaryosis had high-grade CIN. The presence of koilocytosis (24% for borderline smears and 34% for mild dyskaryotic smears) did not appear to influence the risk of developing high-grade CIN. Our results suggest that the simultaneous implementation of the British Society for Clinical Cytology proposed terminology and the colposcopy guidelines from the British Society for Colposcopy and Cervical Pathology could have an impact on colposcopy services.

Notizen: A comparative study: conventional preparation and ThinPrep 2000 in respiratory cytology In order to compare and contrast conventional preparation (CP) with ThinPrep® 2000 (TP) in respiratory cytology, 207 samples were divided equally and processed by the two different preparation methods, generating three CP and one TP slide per sample. No lesion identified by CP was missed by TP and there were no significant differences between TP and CP in the diagnostic categories. However, two cases of squamous cell carcinoma were detected on TP which had been classified as unsatisfactory and moderate squamous dyskaryosis, respectively, on CP. ThinPrep was found to be superior to CP in many respects as it provided standardized preparations in a greater proportion of cases and problems such as cell overlapping and background debris were markedly reduced. In several instances the diagnostic accuracy in CP was compromised by smears that were either too thick, too thin, or too scanty. Cell preservation was also better on TP when compared with CP, facilitating more accurate diagnosis and significantly reducing the primary screening and reporting time, especially of sputum samples. A major advantage of TP methodology is the fact that it facilitates optimal use of skilled cytotechnologists and streamlines the workflow in the laboratory.