ISSN:
1573-6830
Keywords:
electroconvulsive shock
;
lithium
;
norepinephrine
;
cortical vesicles
;
K+-evoked release
;
clonidine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary 1. The effect of repeated electroconvulsive shock (ECS) treatment and chronic LiC1 feeding on calcium-dependent, K+-evoked release of [3H] norepinephrine from rat cortical vesicular preparation was studied. 2. There was no significant effect of either acute or repeated ECS treatment on [3H]norepinephrine release in cortical vesicles obtained from animals treated for either 1 or 10 days. Release of norepinephrine was examined over a range of CaCl2 concentrations. 3. Clonidine effectively inhibited release of [3H]norepinephrine in cortical vesicles obtained from control and ECS-treated animals. 4. K+-evoked release of [3H]norepinephrine at low (0.2 mM) and high (1.0 mM) CaCl2 concentrations was significantly increased in cortical vesicles obtained from LiCl-treated animals. Clonidine effectively inhibited release of [3H]norepinephrine in cortical vesicles obtained from both control and LiCl-fed animals. 5. These results suggest a possible common mechanism of action of antidepressant drug therapy on presynaptic release of norepinephrine from nerve terminals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00710946
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