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  • 1
    Electronic Resource
    Electronic Resource
    Cerebrovascular effects of substance P after experimental subarachnoid haemorrhage (1992)
    Springer
    Acta neurochirurgica 119 (1992), S. 139-145 
    Details
    ISSN: 0942-0940
    Keywords: Substance P ; vasospasm ; subarachnoid haemorrhage ; isometric tension recording ; cyclic GMP ; rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The vasoactive effects of substance P (SP), as well as the content of cyclic guanine monophosphate (cGMP), were determined in the rabbit basilar artery after subarachnoid haemorrhage (SAH). Out of 47 rabbits, 24 were subjected to a SAH, induced by injecting 5ml of autologous arterial blood into the cisterna magna; 23 were used as controls. In 20 animals (10 SAH and 10 controls), isometric tension recording of isolated rings of the basilar artery — dissected 2 days after SAH — was employed to assess the dosedependent vasodilatation to SP (10−10 to 10−6M) after precontraction with serotonin (10−8 to 10−5M). In 15 animals (8 SAH and 7 controls), the basal cGMP content was measured in the basilar artery 2 days after SAH. In the other 12 animals (6 SAH and 6 controls), the increase in cGMP content was measured in the basilar artery after a 10-minute incubation with SP (10−6M). SP caused significantly less dilatation in animals subjected to SAH than in controls, especially for concentrations between 10−9 and 10−6M (p 〈 0.001). The cGMP content in the arteries 2 days after SAH was significantly lower than in control arteries (31.5 ± 7.3 against 57.3 ± 4.3 pmoles/g tissue). In the preparations incubated with SP, the increase of cGMP was 440 ± 115% in the control arteries, and only 97 ± 30% in the arteries after SAH. It is concluded that the vasodilator activity of SP is significantly impaired after SAH. Moreover, the changes in cGMP content after SAH suggest a link between impaired vasoactive response to SP and decreased production of cGMP after SAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541798
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The international cooperative study on timing of aneurysm surgery (1982)
    Springer
    Acta neurochirurgica 63 (1982), S. 119-123 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728863
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Long-Term Follow-Up of Brachytherapy in Untreated Malignant Glioma (1999)
    Springer
    Journal of radiosurgery 2 (1999), S. 129-133 
    Details
    ISSN: 1573-8752
    Keywords: Brachytherapy ; malignant glioma ; brain neoplasm ; astrocytoma ; glioblastoma multiforme ; stereotaxy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Long-term follow-up of patients with malignant glioma randomized to treatment with and without brachytherapy. Methods: Twenty-six patients were randomized to brachytherapy and external radiation, and 23 to external radiation alone. There were 19 and 17 glioblastomas, and 3 and 8 anaplastic astrocytomas, in the nonimplant and implant groups, respectively, and 1 malignant oligodendroglioma in each group. For brachytherapy, iodine- 125 seeds were implanted to deliver a homogeneous dose of 40 cGy/hr for a maximum of 6000 cGy to the enhancing tumor margin. All patients received external radiation for a total of 6020 cGy delivered to the tumor plus 3 cm margin over 7 weeks, followed by BCNU chemotherapy. Conclusions: The median survival was 78 and 66 weeks in the implant and nonimplant groups respectively, and their survival curves were not different (log rank, p=0.394). A significant multivariate relationship did exist between survival and age (p=0.0092), tumor grade (p=0.0001), and Karnofsky (p=0.021). Treatment with brachytherapy is subject to selection bias, which does exclude a large proportion of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022914612628
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    Paper (German National Licenses)
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