ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The conformational behavior of POE-bound model peptides Boc-(L-Ala)2-X-Y-(L-Ala)2-NHPOE (X - Y = L-Pro-Gly (I), Gly-L-Ile (II); NHPOE = aminopoly(oxyethylene)) as well as of the repetitive hexapeptide of elastin, Boc-L-Val-L-Ala-L-Pro-Gly-L-Val-Gly-A-NHPOE-M (III) (A = photosensitive 3-nitro-4-(bromomethyl)benzoyl group; NHPOE-M = aminopoly(oxyethylane) monomethyl ether) has been studied by means of 1H-NMR and CD spectroscopy. Compounds I and III form a β-turn with Pro and Gly in positions i + 1 and i + 2, respectively, while an aggregated state for II, has been identified. The results are in good agreement with published prediction codes giving experimental evidence for the dominance of short-range interactions to establish secondary structure in solution.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19850680320
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