ISSN:
1435-1463
Keywords:
Schizophrenia
;
neuroleptics
;
reserpine
;
cerebrospinal fluid amines
;
metabolites
;
c-AMP
;
serum prolactin
;
enzymes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The clinical and biochemical effects of adjuvant reserpine treatment were investigated in 12 chronic schizophrenic patients on long-term neuroleptic medication. The global severity of the symptoms using the Brief Psychiatric Rating Scale did not change significantly in the whole group, however, a moderate decrease in positive symptoms (factors though disturbance, activation and hostile-suspiciousness) was observed for 5 patients. Cerebrospinal fluid (CSF) noradrenaline levels showed a consistent decrease, but other biochemical parameters (CSF dopamine metabolites, platelet MAO and serum dopamine-β-hydroxylase activities) did not change significantly. The changes of clinical symptoms and biochemical parameters did not show any correlation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01259412
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