ISSN:
1573-8221
Keywords:
liver
;
sinusoidal cells
;
endotheliocytes
;
Kupffer cells
;
lipocytes
;
3,4-benzopyrene
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Reorganization of sinusoidal cells (endotheliocytes, Kupffer cells, and Ito cells) in the liver microregion of male rat liver exposed to 3,4-benzopyrene was studied. Synchronous activation of the lysosome-vacuole systems in Kupffer cells and endotheliocyte indicates cooperation of these cells in detoxification of benzopyrene and its metabolites. Ito cells lose lipid inclusions and actively proliferate; the appearance of intermediate forms between lipocytes and fibroblasts attests to activation of fibrogenesis in the liver.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1017500622380
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