Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Pacing and clinical electrophysiology
23 (2000), S. 0
ISSN:
1540-8159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation (DEFINITE) is a multicenter randomized trial. Patients will have nonischemic Cardiomyopathy (LVEF ± 35%), a history of symptomatic heart fail-ure and spontaneous arrhythmia (〉 10 PVCs/hour or nonsustained ventricular tachycardia defined as 3-15 beats at a rate of 〉 120 beats/min) on Holter monitor or telemetry within the past 6 months. Patients will be randomized to an implantable cardioverter defibrillator (ICD) versus no ICD. All patients will re-ceive standard oral medical therapy for heart failure including angiotensin converting enzyme inhibitors and β-blockers (if tolerated). Patients will be followed for 2-3 years. The primary endpoint will be total mortality. Quality-of-life and pharmacoeconomics analyses will also be performed. A registry will track patients who meet basic inclusion criteria but are not randomized. We estimate an annual total mortality of 15% at 2 years in the treatment arm that does not receive an ICD. The ICD is expected to reduce mor-tality by 50%. Approximately 204 patients will be required in each treatment group. Twenty-five centers will be included in a trial designed to last an estimated 4 years.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1540-8159.2000.tb06759.x
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